Vélez Jaramillo Yanet, Reveiz Montes Marco Antonio, Galván-Barrios Johana Patricia, Picón-Jaimes Yelson Alejandro
Sub Secretary of Health Protection and Service Provision - District Public Health Secretariat, Cali, Colombia.
University of Costa Rica, San José, Costa Rica.
Infez Med. 2025 Mar 1;33(1):15-28. doi: 10.53854/liim-3301-3. eCollection 2025.
Dengue is a mosquito-borne viral disease. It has been associated with high maternal and foetal morbidity and mortality. Therefore, this study aimed to describe the outcomes of Dengue infection in pregnant women in terms of maternal bleeding, miscarriage, preterm delivery, severe Dengue, Dengue shock and maternal mortality, as well as foetal outcomes in terms of foetal distress, low birth weight and neonatal mortality.
This systematic review followed PRISMA guidelines and was PROSPERO-registered (CRD42024578212). It examined publications from 2019-2024 across major databases, including Medline, Scopus, Web of Science, Scielo, and CENTRAL. The selection process utilised Rayyan AI for duplicate removal, followed by a two-reviewer screening system. The two reviewers initially filtered the papers by title and, then, by abstract; finally, they read the full text and chose the articles to synthesise. The same two reviewers performed data extraction independently using a Microsoft Excel matrix. For the risk of bias assessment and Quality evaluation, the ROBINS-E tool and the STROBE guidelines were employed.
Maternal Dengue was associated with an increased risk of preterm delivery and complications such as obstetric bleeding, especially postpartum haemorrhage, which was a complication that reached proportions of up to 25% in some studies. Severe Dengue and Dengue shock were also complications present in these women; thrombocytopenia was the most common sign, and complications such as pre-eclampsia and multi-organ dysfunction appeared, leading to fatal outcomes such as maternal and foetal mortality.
Dengue infection during gestation carries significant maternal health risks, including complications such as bleeding, miscarriage and preterm delivery. In addition, it is associated with foetal distress and low birth weight, as well as increased foetal and neonatal mortality, highlighting the need for vigilance and appropriate medical care.
登革热是一种由蚊子传播的病毒性疾病。它与孕产妇和胎儿的高发病率和死亡率有关。因此，本研究旨在描述孕妇感染登革热后的结局，包括孕产妇出血、流产、早产、重症登革热、登革热休克和孕产妇死亡，以及胎儿结局，如胎儿窘迫、低出生体重和新生儿死亡。
本系统评价遵循PRISMA指南，并在PROSPERO注册（CRD42024578212）。它检索了2019年至2024年各大数据库的出版物，包括Medline、Scopus、Web of Science、Scielo和CENTRAL。筛选过程利用Rayyan AI去除重复项，然后采用双审筛选系统。两位审稿人首先按标题筛选论文，然后按摘要筛选；最后，他们阅读全文并选择要综合的文章。同样的两位审稿人使用Microsoft Excel矩阵独立进行数据提取。对于偏倚风险评估和质量评估，采用了ROBINS-E工具和STROBE指南。
孕产妇感染登革热与早产风险增加以及产科出血等并发症有关，尤其是产后出血，在某些研究中，这一并发症的发生率高达25%。重症登革热和登革热休克也是这些女性出现的并发症；血小板减少是最常见的体征，还出现了先兆子痫和多器官功能障碍等并发症，导致孕产妇和胎儿死亡等致命结局。
孕期感染登革热对孕产妇健康有重大风险，包括出血、流产和早产等并发症。此外，它还与胎儿窘迫和低出生体重以及胎儿和新生儿死亡率增加有关，凸显了警惕和适当医疗护理的必要性。
