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Sarcopenia and frailty in critical illness.

作者信息

van der Steen-Dieperink Marielle Johanna Maria Magdalena, Koekkoek Wilhelmina Aria Christina, Kouw Imre Willemijn Kehinde

机构信息

Department of Intensive Care Medicine, Martini Hospital, Groningen.

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen.

出版信息

Curr Opin Clin Nutr Metab Care. 2025 May 1;28(3):192-199. doi: 10.1097/MCO.0000000000001123. Epub 2025 Mar 12.


DOI:10.1097/MCO.0000000000001123
PMID:40072495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11970596/
Abstract

PURPOSE OF REVIEW: Sarcopenia and frailty are common conditions, associated with worse clinical outcomes during critical illness. Recent studies on sarcopenia and frailty in ICU patients are presented in this review, aiming to identify accurate diagnostic tools, investigate the effects on clinical and functional outcomes, and propose possible effective interventions. RECENT FINDINGS: The recent change of the sarcopenia definition underlines the importance of muscle strength over mass, this is however challenging to assess in ICU patients. There is currently no unified sarcopenia definition, nor standard frailty assessment tool; Clinical Frailty Scale is most frequently used in the ICU. Meta-analyses show worse clinical and functional outcomes for frail as well as sarcopenic patients admitted to the ICU, regardless of admission diagnosis. Frailty is a dynamic condition, worsening in severity by the time of hospital discharge, but showing improvement by 6 months post-ICU. Therapeutic interventions for frailty and sarcopenia remain limited. Although mobilization strategies show promise in improving functional and cognitive outcomes, inconsistent outcomes are reported. Heterogeneity in definitions, patient populations, and care practices challenge interpretation and comparison of study results and recognition of beneficial interventions. This highlights the need for more research. SUMMARY: The importance of preexisting sarcopenia and frailty is recognized in ICU patients and associated with worse clinical outcomes. Multidimensional interventions are most promising, including patient-tailored mobilization and nutrition.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b192/11970596/8ad148bae9e6/cocnm-28-192-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b192/11970596/e94192698eeb/cocnm-28-192-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b192/11970596/8ad148bae9e6/cocnm-28-192-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b192/11970596/e94192698eeb/cocnm-28-192-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b192/11970596/8ad148bae9e6/cocnm-28-192-g002.jpg

相似文献

[1]
Sarcopenia and frailty in critical illness.

Curr Opin Clin Nutr Metab Care. 2025-5-1

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
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引用本文的文献

[1]
Prevalence and characteristics of sarcopenic obesity and normal weight obesity in Chinese women: a cross-sectional study based on body fat percentage.

BMC Public Health. 2025-8-18

[2]
The Role of the Mediterranean Diet in the Prevention of Sarcopenia and Frailty in Older Adults: A Narrative Review.

Nutrients. 2025-5-21

本文引用的文献

[1]
Quadriceps Muscle Layer Thickness and its association with frailty in critically ill patients: A prospective observational study.

J Crit Care. 2025-2

[2]
Frailty and 6-month trajectory of elderly trauma patients over the age of 65 years admitted to intensive care unit for severe trauma: experience of a level 1 trauma center.

BMC Geriatr. 2024-9-14

[3]
Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands.

Lancet. 2024-8-17

[4]
Comparison between Effect of Indirect Calorimetry vs Weight-based Equation (25 kcal/kg/day)-guided Nutrition on Quadriceps Muscle Thickness as Assessed by Bedside Ultrasonography in Medical Intensive Care Unit Patients: A Randomized Clinical Trial.

Indian J Crit Care Med. 2024-6

[5]
Guideline on positioning and early mobilisation in the critically ill by an expert panel.

Intensive Care Med. 2024-8

[6]
The impact of frailty on survival times up to one year among patients admitted to ICU with in-hospital cardiac arrest.

J Crit Care. 2024-10

[7]
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study.

Intensive Care Med. 2024-7

[8]
Indirect calorimetry directed feeding and cycling in the older ICU population: a pilot randomised controlled trial.

BMC Anesthesiol. 2024-5-7

[9]
Efficacy of the "Start to move" protocol on functionality, ICU-acquired weakness and delirium: A randomized clinical trial.

Med Intensiva (Engl Ed). 2024-4

[10]
Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial.

Crit Care. 2023-12-15

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