Tazi-Lakhassi L, Benbachir M, el Mdaghri N, Zaghloul J
J Int Med Res. 1985;13(3):188-95. doi: 10.1177/030006058501300308.
The pharmacokinetics of amoxycillin in the CSF following intravenous and oral administration at a 150 mg/kg per day or 250 mg/kg per day dosage in the treatment of purulent meningitis is described. A significant correlation between meningeal inflammation and CSF levels of amoxycillin were observed, including a correlation between the initial neurological state and the outcome of the illness. Despite the early introduction of oral therapy and the reduction in dosage following meningeal and pneumococcal meningitis, no treatment failures could be attributed to this therapeutic regime. Such a treatment schedule, moreover, reduces the risk of superinfection in hospital as well as the cost of treatment and aids the comfort to the patient.
描述了在治疗化脓性脑膜炎时，每日静脉注射和口服剂量为150mg/kg或250mg/kg的阿莫西林在脑脊液中的药代动力学。观察到脑膜炎症与脑脊液中阿莫西林水平之间存在显著相关性，包括初始神经状态与疾病转归之间的相关性。尽管早期引入了口服治疗并在治疗脑膜和肺炎球菌脑膜炎后降低了剂量，但该治疗方案未导致任何治疗失败。此外，这样的治疗方案降低了医院内二重感染的风险、治疗成本，并有助于提高患者的舒适度。
