Haquani A H, Channa N M, Farooq S
J Pak Med Assoc. 1977 May;27(5):323-4.
Amoxycillin a new broad spectrum antibiotic has been found to be effective against common gram positive and negative bacteria diagnosed in clinical practice. Moreover, it achieves higher blood levels as compared to Ampicillin. Since it was available only for oral use it had not been tried in the treatment of bacterial meningitis. Recently Amoxycillin Trihydrate became available for parenteral administration. Here we report its use as a single drug in 11 cases of Pyogenic meningitis. The dose administered by intravenous route was 200-400 mg/kg/day. All the cases recovered. Only three had minor neurological sequelae. Amoxycillin Trihydrate appears to be a safe and effective drug as there were no side effects or toxic manifestation even with the high dosage schedule.
阿莫西林是一种新型广谱抗生素，已发现它对临床诊断出的常见革兰氏阳性和阴性细菌有效。此外，与氨苄青霉素相比，它能达到更高的血药浓度。由于它仅可供口服使用，因此尚未尝试用于治疗细菌性脑膜炎。最近，三水合阿莫西林可供肠胃外给药。在此我们报告其作为单一药物用于11例化脓性脑膜炎的情况。静脉途径给药剂量为200 - 400毫克/千克/天。所有病例均康复。只有三例有轻微的神经后遗症。三水合阿莫西林似乎是一种安全有效的药物，因为即使采用高剂量方案也没有副作用或毒性表现。
