Silverberg Jonathan I, Anderson Peter, Cappelleri Joseph C, Piercy James, Levenberg Mark E, Myers Daniela E, Gerber Robert A
George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Adelphi Real World, Bollington, UK.
Arch Dermatol Res. 2025 Mar 12;317(1):556. doi: 10.1007/s00403-025-03910-y.
Few studies explore the burden of mild-to-moderate atopic dermatitis (AD). We aimed to investigate disease burden in mild-to-moderate AD using real-world data from adults with AD and their physicians in the United States. Data were drawn from the Adelphi Real World AD Disease Specific Programme™, a cross-sectional survey of physicians and their patients with AD in real-world clinical practice in the US from November 2014 to February 2015. Physicians provided data for the next five eligible adults who consulted the physician. Patients had a physician-reported history of moderate-to-severe AD. Overall, 284 and 554 adults with physician-perceived mild or moderate AD at the most recent consultation, respectively, were included in the analysis. Patients with moderate AD experienced more flares (p <.001) and had dry skin, pruritus, and cracking/raw skin day-to-day that were more severe (p <.0001) and when experiencing a flare (p <.05) than patients with mild AD. Adults with either mild or moderate AD used a similar number of treatments. Patients with moderate AD reported greater impact on health status, health-related quality of life, and productivity than those with mild AD. Adults with mild-to-moderate AD experienced substantial daily impact from symptoms despite multiple therapies. Unmet needs remain and more can be done to improve disease control in adults with mild-to-moderate AD.
很少有研究探讨轻度至中度特应性皮炎（AD）的负担。我们旨在利用来自美国成年AD患者及其医生的真实世界数据，调查轻度至中度AD的疾病负担。数据取自阿德尔菲真实世界AD疾病特定项目™，这是一项对2014年11月至2015年2月在美国真实临床实践中的医生及其AD患者进行的横断面调查。医生为接下来五位符合条件并前来咨询的成年人提供数据。患者有医生报告的中度至重度AD病史。总体而言，分析纳入了在最近一次会诊中医生认为患有轻度或中度AD的284名和554名成年人。与轻度AD患者相比，中度AD患者经历了更多的病情发作（p <0.001），日常出现的皮肤干燥、瘙痒和皮肤皲裂/破损更严重（p <0.0001），在病情发作时也更严重（p <0.05）。轻度或中度AD的成年人使用的治疗方法数量相似。与轻度AD患者相比，中度AD患者报告对健康状况、健康相关生活质量和生产力的影响更大。尽管进行了多种治疗，轻度至中度AD的成年人仍每天受到症状的严重影响。未满足的需求仍然存在，在改善轻度至中度AD成年人的疾病控制方面还有更多工作可做。
