Kim Jaeryung, Park Kyung-Ah, Han Kyungdo, Jung Jin-Hyung, Oh Sei Yeul, Rhiu Soolienah
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
PLoS One. 2025 Mar 12;20(3):e0319872. doi: 10.1371/journal.pone.0319872. eCollection 2025.
This study investigates whether ocular motor cranial neuropathy (OMCN) can predict the onset of thyroid cancer given its association with common cardiovascular risk factors including obesity, diabetes mellitus (DM), hypertension, and dyslipidemia. We conducted a retrospective, nationwide, population-based cohort study utilizing data from the Korean National Health Insurance Service. Individuals comprised those aged ≥ 20 years diagnosed with OMCN between 2010 and 2017. Exclusions were based on pre-existing conditions, inability to match controls, or incomplete data. The study involved 118,686 participants, with 19,781 in the OMCN group and 98,905 controls, matched for age and sex. Patients with OMCN showed a significantly higher risk of developing thyroid cancer (hazard ratio [HR] = 1.392 [95% confidence interval, 1.075-1.802]) compared to controls after adjusting for potential confounding factors. This association was more pronounced in participants with DM and women (HR = 2.288 in DM vs. HR = 1.209 in non-DM, p = 0.0450; HR = 1.677 in females vs. HR = 0.824 in males, p = 0.0246). The findings suggest OMCN as a potential early predictor of thyroid cancer risk, particularly in diabetic and female patients. Further research is needed to explore the underlying mechanisms linking cardiovascular risk factors to the relationship between OMCN and thyroid cancer. Proactive management of these risk factors in OMCN patients may contribute to thyroid cancer prevention.
本研究探讨眼动性颅神经病变（OMCN）与肥胖、糖尿病（DM）、高血压和血脂异常等常见心血管危险因素相关联时，是否能够预测甲状腺癌的发病情况。我们利用韩国国民健康保险服务的数据，开展了一项全国性、基于人群的回顾性队列研究。研究对象为2010年至2017年间诊断为OMCN的≥20岁个体。排除标准基于既往存在的疾病、无法匹配对照组或数据不完整。该研究涉及118,686名参与者，其中OMCN组有19,781人，对照组有98,905人，两组在年龄和性别上进行了匹配。在调整潜在混杂因素后，与对照组相比，OMCN患者发生甲状腺癌的风险显著更高（风险比[HR]=1.392[95%置信区间，1.075 - 1.802]）。这种关联在糖尿病患者和女性中更为明显（糖尿病患者的HR = 2.288，非糖尿病患者的HR = 1.209，p = 0.0450；女性的HR = 1.677，男性的HR = 0.824，p = 0.0246）。研究结果表明，OMCN可能是甲状腺癌风险的潜在早期预测指标，尤其是在糖尿病患者和女性患者中。需要进一步研究以探索将心血管危险因素与OMCN和甲状腺癌之间关系联系起来的潜在机制。对OMCN患者这些危险因素进行积极管理可能有助于预防甲状腺癌。
