Peterson D P, Bhattacharyya M H
Fundam Appl Toxicol. 1985 Jun;5(3):499-505. doi: 10.1016/0272-0590(85)90097-1.
Hematological responses of mice to arsine exposures for 1 hr at 5 to 26 part per million volume (ppmv) are described. Exposure concentrations ranged from a no-effect level for the endpoints studied (5 ppmv) to a concentration lethal to all mice in 4 days (26 ppmv). Hematocrit values at 24 hr after exposure decreased linearly with increasing arsine concentration in the range 5 to 26 ppmv; the hematocrit of the 26-ppmv group reached 10.5% at 24 hr, compared to 48.4% for control mice. Hematocrits of mice from all surviving groups were at or slightly above control values by 11 days after exposure. Changes in numbers of erythrocytes paralleled changes in hematocrit. Significant increases in circulating reticulocytes occurred at 1 and 5 days after exposure; reticulocyte values returned to control levels by 11 days after exposure. Changes in erythrocyte osmotic fragility were observed in mice exposed to 15 and 26 ppmv arsine.
描述了小鼠在百万分比体积（ppmv）为5至26的情况下暴露于胂1小时后的血液学反应。暴露浓度范围从所研究终点的无效应水平（5 ppmv）到4天内对所有小鼠致死的浓度（26 ppmv）。暴露后24小时的血细胞比容值在5至26 ppmv范围内随胂浓度增加呈线性下降；26 ppmv组在24小时时血细胞比容降至10.5%，而对照小鼠为48.4%。暴露后11天，所有存活组小鼠的血细胞比容达到或略高于对照值。红细胞数量的变化与血细胞比容的变化平行。暴露后1天和5天循环网织红细胞显著增加；暴露后11天网织红细胞值恢复到对照水平。在暴露于15和26 ppmv胂的小鼠中观察到红细胞渗透脆性的变化。
