使用佛罗里达大学（UF）体模对锝-二巯丁二酸（Tc-DMSA）、-巯基乙酰三甘氨酸（Tc-MAG3）和-二乙三胺五乙酸（Tc-DTPA）单光子发射计算机断层显像（SPECT）成像中患者吸收剂量进行基于蒙特卡洛方法的估算。
Monte Carlo-based estimation of patient absorbed dose in Tc-DMSA, -MAG3, and -DTPA SPECT imaging using the University of Florida (UF) phantoms.
作者信息
Khoshyari Zeynab, Jahangir Reza, Miri-Hakimabad Hashem, Mohammadi Najmeh, Arabi Hossein
机构信息
Department of Physics, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Medical Radiation Engineering, Shahid Beheshti University, Tehran, Iran.
出版信息
Appl Radiat Isot. 2025 Jun;220:111772. doi: 10.1016/j.apradiso.2025.111772. Epub 2025 Mar 6.
It is generally accepted that children's organs are more sensitive to radiation than adults, due to their growth rate. Therefore, evaluating the absorbed dose in children to avoid irrecoverable damage is highly crucial. In this work, absorbed dose by different organs of children within the SPECT imaging for the Tc-MAG3, Tc-DTPA, and Tc-DMSA that are commonly employed for pediatric patients, were estimated through the use of Monte Carlo simulation and the University of Florida's (UF) voxel-wise phantoms at the ages of 4, 8, 11, and 14-years old. The results showed that the highest absorbed dose was by kidneys and when Tc-DMSA was used. Also, the highest and lowest absorbed dose in the organs occurred when Tc-DMSA and Tc-MAG3 were used, respectively. The simulation results were in good agreement with the ICRP 128 data.
由于儿童的生长速度，人们普遍认为儿童的器官对辐射比成人更敏感。因此，评估儿童的吸收剂量以避免不可恢复的损伤至关重要。在这项工作中，通过使用蒙特卡罗模拟和佛罗里达大学（UF）的体素模型，对4岁、8岁、11岁和14岁儿童在用于儿科患者的常用的Tc-MAG3、Tc-DTPA和Tc-DMSA的SPECT成像中不同器官的吸收剂量进行了估计。结果表明，当使用Tc-DMSA时，肾脏的吸收剂量最高。此外，分别使用Tc-DMSA和Tc-MAG3时，器官中的吸收剂量最高和最低。模拟结果与ICRP 128数据吻合良好。
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