Caldiroli Cristina Liviana, Sarandacchi Silvia, Tomasuolo Miriam, Diso Deborah, Castiglioni Marco, Procaccia Rossella
Department of Human Sciences for Education "Riccardo Massa", University of Milano-Bicocca, Milan, Italy.
Department of Economics, Management and Statistics, University of Milano Bicocca, Milan, Italy.
Sci Rep. 2025 Mar 12;15(1):8599. doi: 10.1038/s41598-025-93008-2.
Quality of life is a critical outcome in oncology, influencing treatment adherence and patient satisfaction. Haematology patients face psychological challenges, including emotional distress, depression and PTSD, which can affect their quality of life. Resilience and social support are protective factors that help patients cope with these challenges. This study aimed to assess the psychological adjustment of haematology patients by examining psychological outcomes (PTSD and depression), psychological resources (resilience and perceived social support), and quality of life. It also examined correlations between demographic variables, psychological outcomes and resources to identify predictors of quality of life and whether resilience mediates these effects. A sample of 110 haematology patients from three hospital centers in central/southern Italy participated. Data were collected using self-report questionnaires measuring PTSD, depression, resilience, social support and quality of life. Correlational analyses and hierarchical multiple regression were used to explore the relationships between variables, followed by a mediation analysis to examine the role of resilience. Results indicated that QOL was negatively associated with gender, age, PTSD and depression, but positively associated with resilience. Regression analyses showed that quality of life was significantly predicted by resilience, age, depressive symptoms and gender. The mediation model showed that resilience partially mediated the effects of age, gender and depression on QoL. These findings highlight the protective role of resilience in improving quality of life in haematology patients. Despite limitations related to sample size and the use of self-report questionnaires, this study provides valuable insights into the psychological adjustment of haematology patients and highlights the importance of considering psychological resources in oncology care.
生活质量是肿瘤学中的一个关键结果，影响治疗依从性和患者满意度。血液学患者面临心理挑战，包括情绪困扰、抑郁和创伤后应激障碍，这些都会影响他们的生活质量。复原力和社会支持是帮助患者应对这些挑战的保护因素。本研究旨在通过检查心理结果（创伤后应激障碍和抑郁）、心理资源（复原力和感知到的社会支持）和生活质量来评估血液学患者的心理调适情况。它还研究了人口统计学变量、心理结果和资源之间的相关性，以确定生活质量的预测因素，以及复原力是否介导了这些影响。来自意大利中南部三个医院中心的110名血液学患者参与了样本研究。使用自我报告问卷收集数据，这些问卷测量创伤后应激障碍、抑郁、复原力、社会支持和生活质量。使用相关分析和分层多元回归来探索变量之间的关系，随后进行中介分析以检验复原力的作用。结果表明，生活质量与性别、年龄、创伤后应激障碍和抑郁呈负相关，但与复原力呈正相关。回归分析表明，生活质量由复原力、年龄、抑郁症状和性别显著预测。中介模型表明，复原力部分介导了年龄、性别和抑郁对生活质量的影响。这些发现突出了复原力在改善血液学患者生活质量方面的保护作用。尽管存在与样本量和使用自我报告问卷相关的局限性，但本研究为血液学患者的心理调适提供了有价值的见解，并强调了在肿瘤护理中考虑心理资源的重要性。
