Sepúlveda-Robles Omar, Flores-Lujano Janet, Núñez-Enríquez Juan Carlos, Jiménez-Hernández Elva, Duarte-Rodríguez David Aldebarán, Martín-Trejo Jorge Alfonso, Espinoza-Hernández Laura Eugenia, García-Jiménez Xochiketzalli, Paredes-Aguilera Rogelio, Dosta-Herrera Juan José, Mondragón-García Javier Anastacio, Valdés-Guzmán Heriberto, Mejía-Pérez Laura, Espinoza-Anrubio Gilberto, Paz-Bribiesca María Minerva, Salcedo-Lozada Perla, Landa-García Rodolfo Ángel, Ramírez-Colorado Rosario, Hernández-Mora Luis, Santamaría-Ascencio Marlene, López-Loyola Anselmo, Godoy-Esquivel Arturo Hermilo, García-López Luis Ramiro, Anguiano-Ávalos Alison Ireri, Mora-Rico Karina, Castañeda-Echevarría Alejandro, Rodríguez-Jiménez Roberto, Cibrian-Cruz José Alberto, Cárdenas-Cardos Rocío, Altamirano-García Martha Beatriz, Sánchez-Ruiz Martin, Rivera-Luna Roberto, Rodríguez-Villalobos Luis Rodolfo, Hernández-Pérez Francisco, Olvera-Durán Jaime Ángel, García-Cortés Luis Rey, Torres-Nava José Refugio, De Ita Marlon, Medina-Sanson Aurora, Mata-Rocha Minerva, Peñaloza-Gonzalez José Gabriel, Espinosa-Elizondo Rosa Martha, Flores-Villegas Luz Victoria, Amador-Sanchez Raquel, Orozco-Ruiz Darío, Pérez-Saldívar Maria Luisa, Velázquez-Aviña Martha Margarita, Merino-Pasaye Laura Elizabeth, Solís-Labastida Karina Anastacia, González-Ávila Ana Itamar, Santillán-Juárez Jessica Denisse, Bekker-Méndez Vilma Carolina, Jiménez-Morales Silvia, Rangel-López Angélica, Arellano-Galindo José, Meléndez-Zajgla Jorge, Rosas-Vargas Haydeé, Mejía-Aranguré Juan Manuel
Unidad de Investigación Médica en Genética Humana, UMAE Hospital de Pediatría, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City 06720, Mexico.
Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Pediatría, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City 06720, Mexico.
Cancers (Basel). 2025 Feb 21;17(5):733. doi: 10.3390/cancers17050733.
BACKGROUND: The few epidemiologic studies of infection exposure in early life and acute leukemia (AL) risk in Latino children have yielded inconsistent results, suggesting a possible effect of ethnicity. Here, we examined the correlation between infection exposure and acute leukemia risk in children from Mexico City-One of the biggest Latino cities worldwide. METHODS: This study included 1455 Mexican children diagnosed with de novo AL (2002-2016), and 1455 control individuals frequency-matched by age and health institution. The AL population included acute lymphoblastic leukemia (ALL), Pre-B ALL, and acute myeloblastic leukemia (AML). Logistic regression analyses were performed to investigate direct and indirect proxies of infection in children or their mothers. RESULTS: Upper respiratory tract infections during the child's first year of life were a risk factor for AL (OR, 2.76; 95% CI, 1.48-5.15), including ALL (OR, 3.14; 95% CI, 1.67-5.89) and Pre-B (OR, 3.11; 95% CI, 1.63-5.96). Mother's infections before and during pregnancy were protective factors against AL (OR, 0.55; 95% CI, 0.47-0.64; and OR, 0.61; 95% CI, 0.52-0.72, respectively). These associations included ALL and Pre-B. In contrast, only mothers' infections before pregnancy and respiratory tract infections were protective factors against AML (OR, 0.45; 95% CI, 0.33-0.62; and OR, 0.50; 95% CI, 0.37-0.68, respectively). CONCLUSIONS: Infections during the first year of life were associated with AL development in children of Mexico City. Additionally, mothers' exposure to respiratory tract infections before and during pregnancy reduced the AL risk in this Latino population.
背景：关于拉丁裔儿童早年感染暴露与急性白血病（AL）风险的少数流行病学研究结果并不一致，这表明种族可能存在影响。在此，我们研究了来自全球最大的拉丁裔城市之一墨西哥城的儿童感染暴露与急性白血病风险之间的相关性。 方法：本研究纳入了1455名诊断为初发AL的墨西哥儿童（2002 - 2016年），以及1455名按年龄和医疗机构进行频率匹配的对照个体。AL人群包括急性淋巴细胞白血病（ALL）、前B-ALL和急性髓细胞白血病（AML）。进行逻辑回归分析以研究儿童或其母亲感染的直接和间接代理指标。 结果：儿童出生后第一年的上呼吸道感染是AL的一个危险因素（OR，2.76；95%CI，1.48 - 5.15），包括ALL（OR，3.14；95%CI，1.67 - 5.89）和前B-ALL（OR，3.11；95%CI，1.63 - 5.96）。母亲在怀孕前和怀孕期间的感染是AL的保护因素（OR分别为0.55；95%CI，0.47 - 0.64；以及OR，0.61；95%CI，0.52 - 0.72）。这些关联包括ALL和前B-ALL。相比之下，只有母亲怀孕前的感染和呼吸道感染是AML的保护因素（OR分别为0.45；95%CI，0.33 - 0.62；以及OR，0.50；95%CI，0.37 - 0.68）。 结论：墨西哥城儿童出生后第一年的感染与AL的发生有关。此外，母亲在怀孕前和怀孕期间暴露于呼吸道感染可降低该拉丁裔人群的AL风险。
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