Vasconcelos Carlos, Peralta Miguel, Marques Adilson
Higher School of Education of Viseu, Ci&DEI, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal.
CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, 1495-751 Cruz Quebrada, Portugal.
Cancers (Basel). 2025 Feb 23;17(5):754. doi: 10.3390/cancers17050754.
Depression is influenced by a multitude of interconnected factors, including cancer and handgrip strength. The purpose of our study is to examine how handgrip strength and cancer diagnosis are individually and jointly associated with depression. An observational study was employed using secondary data from the Survey of Health, Aging, and Retirement in Europe waves 7 and 8. The sample comprised 7 641 participants (71.1 ± 7.7 years), from 12 European countries. Having a cancer diagnosis was associated with greater odds of depression (depression 2017 model: OR = 1.35, 95% CI = 1.03, 1.75; depression 2019 model: OR = 1.48, 95% CI = 1.12, 1.95). Being in a higher handgrip tertile was associated with lower odds of depression (depression 2017 model: tertile 2, OR = 0.65, 95% CI = 0.56, 0.74 and tertile 3, OR = 0.56, 95% CI = 0.49, 0.65; depression 2019 model: tertile 2, OR = 0.74, 95% CI = 0.64, 0.86 and tertile 3, OR = 0.76, 95% CI = 0.65, 0.88). The greatest reduction in odds for depression was found for participants without cancer and in the third handgrip strength tertile (depression 2017: OR = 0.42, 95% CI = 0.29, 0.61; depression 2019: OR = 0.40, 95% CI = 0.28, 0.58). Both cancer and handgrip strength were associated with depression, with the first increasing its risk and the latter reducing it. Individuals without cancer and in the highest tertile of handgrip strength have lower odds of depression in both analyses.
抑郁症受多种相互关联的因素影响，包括癌症和握力。我们研究的目的是探讨握力和癌症诊断如何分别以及共同与抑郁症相关联。我们采用了一项观察性研究，使用来自欧洲健康、老龄化和退休调查第7波和第8波的二手数据。样本包括来自12个欧洲国家的7641名参与者（71.1±7.7岁）。患有癌症诊断与患抑郁症的几率更高相关（2017年抑郁症模型：OR = 1.35，95% CI = 1.03，1.75；2019年抑郁症模型：OR = 1.48，95% CI = 1.12，1.95）。处于握力较高三分位数与患抑郁症的几率较低相关（2017年抑郁症模型：三分位数2，OR = 0.65，95% CI = 0.56，0.74；三分位数3，OR = 0.56，95% CI = 0.49，0.65；2019年抑郁症模型：三分位数2，OR = 0.74，95% CI = 0.64，0.86；三分位数3，OR = 0.76，95% CI = 0.65，0.88）。在没有癌症且握力处于第三个三分位数的参与者中，患抑郁症的几率下降幅度最大（2017年抑郁症模型：OR = 0.42，95% CI = 0.29，0.61；2019年抑郁症模型：OR = 0.40，95% CI = 0.28，0.58）。癌症和握力均与抑郁症相关，前者增加风险，后者降低风险。在两项分析中，没有癌症且握力处于最高三分位数的个体患抑郁症的几率较低。
