Jovičić-Bata Jelena, Sazdanić-Velikić Danica, Ševo Mirjana, Milanović Maja, Tubić Teodora, Bijelović Milorad, Milošević Nataša, Milić Nataša
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary Oncology, Faculty of Medicine, University of Novi Sad, 21204 Sremska Kamenica, Serbia.
Cancers (Basel). 2025 Mar 3;17(5):864. doi: 10.3390/cancers17050864.
(i) To evaluate the possible exposure of newly diagnosed lung cancer patients to selected lifestyle, environmental, occupational, and dietary risk factors and (ii) to assess the differences in exposures of small-cell (SCLC) and non-small-cell (NSCLC) lung cancer patients to those risk factors.
In this study, 205 newly diagnosed patients with IIIB/IV stage of either SCLC or NSCLC (111 men vs. 94 women) from Vojvodina, Serbia, were surveyed for selected demographic characteristics, dietary and lifestyle habits, and environmental factors.
Most patients were long-term heavy smokers. The body mass index values of SCLC patients were higher than those of NSCLC patients. Women reported higher stress levels compared to men. Women diagnosed with lung adenocarcinoma were more often exposed to traffic pollution compared to men. Individual indoor coal combustion systems were more often used by SCLC patients of both sexes compared to other cancer types. Men were more frequent consumers of canned foods, which are potential sources of endocrine disruptors. Occupational exposure to lung cancer risk factors, in addition to tobacco smoking, may be crucial in lung cancer development with specific occupations.
Further research on environmental and occupational risk factors for lung cancer is urgent in order to unveil the etiopathogenesis of specific lung cancer types.
（i）评估新诊断肺癌患者暴露于特定生活方式、环境、职业和饮食风险因素的可能性，以及（ii）评估小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）患者在这些风险因素暴露方面的差异。
在本研究中，对来自塞尔维亚伏伊伏丁那的205例新诊断为IIIB/IV期SCLC或NSCLC的患者（111名男性对94名女性）进行了调查，了解其特定人口统计学特征、饮食和生活习惯以及环境因素。
大多数患者为长期重度吸烟者。SCLC患者的体重指数值高于NSCLC患者。与男性相比，女性报告的压力水平更高。与男性相比，诊断为肺腺癌的女性更常暴露于交通污染。与其他癌症类型相比，SCLC患者无论男女更常使用个体室内燃煤系统。男性更常食用罐头食品，而罐头食品是潜在的内分泌干扰物来源。除吸烟外，职业暴露于肺癌风险因素在特定职业的肺癌发生中可能至关重要。
迫切需要对肺癌的环境和职业风险因素进行进一步研究，以揭示特定肺癌类型的病因发病机制。
