Ambrogio Francesca, Foti Caterina, Noviello Silvia, Cazzato Gerardo, Meduri Alexandre Raphael, Marasco Carolina, Vacca Angelo, Tirone Benedetta
Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
Internal Medicine 'Guido Baccelli', Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari 'Aldo Moro', AUOC Policlinico di Bari, 70124 Bari, Italy.
Diagnostics (Basel). 2025 Feb 21;15(5):522. doi: 10.3390/diagnostics15050522.
This report discusses a female patient with longstanding discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), refractory to multiple immunosuppressive and biologic treatments. Upon presenting with infiltrated, hypertrophic plaques in facial and décolletage regions, she was started on anifrolumab therapy after the histopathological confirmation of DLE. Following three infusions, significant clinical and dermoscopic improvements were observed, including the resolution of plaques and regression of scarring areas. This case highlights anifrolumab's efficacy in severe lupus skin manifestations, emphasizing its potential to induce dermoscopic and histological remission. Additionally, it suggests that dermoscopy could be a valuable tool for monitoring therapeutic responses in DLE and cutaneous lupus erythematosus, warranting further investigation.
本报告讨论了一名患有长期盘状红斑狼疮（DLE）和系统性红斑狼疮（SLE）的女性患者，该患者对多种免疫抑制和生物治疗均无效。在面部和颈部出现浸润性、肥厚性斑块后，经组织病理学确诊为DLE后，她开始接受阿尼鲁单抗治疗。三次输注后，观察到显著的临床和皮肤镜改善，包括斑块消退和瘢痕区域缩小。该病例突出了阿尼鲁单抗在严重狼疮皮肤表现中的疗效，强调了其诱导皮肤镜和组织学缓解的潜力。此外，这表明皮肤镜可能是监测DLE和皮肤型红斑狼疮治疗反应的有价值工具，值得进一步研究。
