Schattenmann G, Lepsien G, Siewert R
Langenbecks Arch Chir. 1979 Aug;348(4):231-41. doi: 10.1007/BF01317610.
In 36 patients with chronic duodenal ulcer disease LES-function before and after proximal-gastric vagotomy was examined manometrically and by determining pH-values in a prospective study. In addition, esophagus biopsies were taken 5 cm proximal of the cardia. 12 healthy volunteers served as controls. A direct effect of proximal-gastric vagotomy on LES-function could not be shown. On the contrary, in 38,9% of the patients examined, preoperatively proven esophagitis disappears nearly completely 12 months following proximal gastric vagotomy. This positive effect of vagotomy is to be interpreted as a beneficial effect on regurgitated intestinal juice, more so than an effect on cardia function itself.
在一项前瞻性研究中,对36例慢性十二指肠溃疡病患者进行了近端胃迷走神经切断术前和术后的LES功能检查,采用测压法并测定pH值。此外,在贲门近端5 cm处取食管活检组织。12名健康志愿者作为对照。未发现近端胃迷走神经切断术对LES功能有直接影响。相反,在38.9%接受检查的患者中,术前证实的食管炎在近端胃迷走神经切断术后12个月几乎完全消失。迷走神经切断术的这种积极作用应解释为对反流肠液的有益作用,而不仅仅是对贲门功能本身的作用。