Sawada M, Matsui Y, Okudaira Y
Gynecol Oncol. 1985 Jul;21(3):320-30. doi: 10.1016/0090-8258(85)90270-7.
A new line of the human ovarian tumor (poorly differentiated adenocarcinoma), designated OVA-2, has been established by heterotransplantation of the original tumor into athymic nude mice. The donor patient, a 38-year-old woman with stage IV disease, was treated with cis-diamminedichloroplatinum II, Adriamycin, 5-fluorouracil, and VM-26, which were selected in consideration of the results, obtained by experimental chemotherapy of this heterotransplanted tumor. She achieved a complete remission and is alive 15 months after diagnosis. Usefulness of the human tumor-nude mouse system in chemotherapy is reemphasized.
通过将原始肿瘤异种移植到无胸腺裸鼠体内，建立了一种新的人卵巢肿瘤（低分化腺癌）细胞系，命名为OVA-2。供体患者为一名38岁的IV期疾病女性，接受了顺二氯二氨铂II、阿霉素、5-氟尿嘧啶和VM-26治疗，这些药物是根据该异种移植肿瘤的实验化疗结果选择的。她实现了完全缓解，诊断后15个月仍然存活。再次强调了人肿瘤-裸鼠系统在化疗中的实用性。
