Freedman R S, Pihl E, Kusyk C, Gallager H S, Rutledge F
Cancer. 1978 Nov;42(5):2352-9. doi: 10.1002/1097-0142(197811)42:5<2352::aid-cncr2820420536>3.0.co;2-#.
A long-term ovarian carcinoma cell line is described in terms of its morphology, original histopathology, electron microscopic features and chromosome features before and after transplantation into an athymic nude mouse. The microscopic features of the tumor nodule grown in the nude mouse are compared with the original pathology. Epithelial characteristics of the cells were maintained in culture and after retrieval from the nude mouse. Three markers were identified in all karyotypes and trisomy was noted in chromosomes 1, 2, 3, 6, 11, 12, 16, and X and monosomy of 17 and 21.
描述了一种长期培养的卵巢癌细胞系，包括其形态学、原始组织病理学、电子显微镜特征以及移植到无胸腺裸鼠前后的染色体特征。将裸鼠体内生长的肿瘤结节的显微镜特征与原始病理学进行比较。细胞的上皮特征在培养过程中以及从裸鼠体内取出后均得以保持。在所有核型中鉴定出三个标记，并且在染色体1、2、3、6、11、12、16和X上观察到三体性，在染色体17和21上观察到单体性。
