Atsigeida Sofya V, Tuchina Daria K, Timashev Peter S, Tuchin Valery V
Institute of Physics and Science Medical Center, Saratov State University, 410012 Saratov, Russia.
Laboratory of Biophotonics, Tomsk State University, 634050 Tomsk, Russia.
Materials (Basel). 2025 Feb 26;18(5):1035. doi: 10.3390/ma18051035.
The effects of optical clearing of implantable collagen materials were studied using optical clearing agents (OCAs) based on aqueous glucose solutions of various concentrations. By measuring the kinetics of the collimated transmission spectra, the diffusion and permeability coefficients of the OCAs of collagen materials were determined as = (0.22 ± 0.05) × 10 to (1.41 ± 0.05) × 10 cm/c and = (0.55 ± 0.04) × 10 to (1.77 ± 0.07) × 10 cm/c. Studies with optical coherence tomography (OCT) confirmed that each of the OCAs used had an effect on the optical properties of collagen materials, and allowed us to quantify the group refractive indices of the collagen of various samples, which turned out to be in the range from = 1.476 to = 1.579.
使用基于不同浓度葡萄糖水溶液的光学透明剂（OCA）研究了可植入胶原材料的光学透明效果。通过测量准直透射光谱的动力学，确定胶原材料的OCA的扩散系数和渗透系数分别为（0.22±0.05）×10至（1.41±0.05）×10厘米/秒和（0.55±0.04）×10至（1.77±0.07）×10厘米/秒。光学相干断层扫描（OCT）研究证实，所使用的每种OCA均对胶原材料的光学特性有影响，并使我们能够量化各种样品中胶原的群折射率，结果发现其范围为n = 1.476至n = 1.579。
