Bawiec Piotr, Jaworowska Agnieszka, Sawicki Jan, Czop Marcin, Szalak Radosław, Koch Wojciech
Department of Food and Nutrition, Medical University of Lublin, 4a Chodźki Str., 20-093 Lublin, Poland.
Department of Analytical Chemistry, Medical University of Lublin, 4a Chodźki Str., 20-093 Lublin, Poland.
Nutrients. 2025 Feb 20;17(5):748. doi: 10.3390/nu17050748.
Nutrients consumed with food undergo the digestion process, and only some of them are absorbed from the gastrointestinal tract (GI) and enter the bloodstream. Minerals, including Mg, are crucial for maintaining the body's homeostasis, but their beneficial effect depends on their bioavailability, i.e., the part that can be absorbed and used by the body. The bioavailability of nutrients taken in pharmaceutical form is usually higher than the same nutrients contained in food, because their absorption requires prior release from the food matrix.
The main objective of the conducted research was to assess the bioavailability of Mg from dietary supplements and medicinal products, considering the influence of the type of diet and pharmaceutical form on bioavailability.
The experiments were conducted using a previously developed and optimized two-stage in vitro digestion model using cellulose dialysis tubes and ICP-OES method. The influence of three types of diets-standard, basic and high-residue-on the bioavailability of Mg was evaluated.
The bioavailability of Mg from the studied diets was within the range of 48.74-52.51%.
In the models studied, it was observed that the factors influencing bioavailability were the nutritional composition of the diets and the chemical form of Mg.
与食物一起摄入的营养物质会经历消化过程，其中只有一部分会从胃肠道（GI）被吸收并进入血液循环。包括镁（Mg）在内的矿物质对于维持人体的内稳态至关重要，但其有益效果取决于它们的生物利用度，即人体能够吸收和利用的部分。以药物形式摄入的营养物质的生物利用度通常高于食物中所含的相同营养物质，因为它们的吸收需要先从食物基质中释放出来。
开展本研究的主要目的是评估膳食补充剂和药品中镁的生物利用度，同时考虑饮食类型和药物形式对生物利用度的影响。
实验采用先前开发并优化的两阶段体外消化模型，使用纤维素透析管和电感耦合等离子体发射光谱法（ICP-OES）。评估了三种饮食类型——标准饮食、基础饮食和高残渣饮食——对镁生物利用度的影响。
所研究饮食中镁的生物利用度在48.74%至52.51%的范围内。
在所研究的模型中，观察到影响生物利用度的因素是饮食的营养成分和镁的化学形式。
