Ohnhaus E E, Noelpp U B, Ramos M R
Hepatogastroenterology. 1985 Apr;32(2):61-4.
An increased liver blood flow in rats and monkeys found following induction of the liver microsomal enzyme system by antipyrine and phenobarbitone, formed the basis of the present study in 7 volunteers. The total body clearance of antipyrine, gamma GT, and the urinary excretion of d-glucaric acid and 6-beta-hydroxycortisol were measured. Liver blood flow was estimated after an overnight fast under basal conditions using the 133Xenon inhalation technique. In addition, liver volume was determined by 7 independent investigations using a 99mTechnetium-sulfur-colloid scan of the liver. Afterwards, each volunteer received 1,000 mg antipyrine daily for 14 days and all measurements were repeated. After antipyrine administration the antipyrine half-life decreased significantly from 12.5 to 7.7 hours with an increase of the antipyrine clearance from 34.1 to 50.8 ml/min. In addition, glucaric acid, gamma-GT and 6-beta-hydroxycortisol were significantly increased. Liver blood flow increased from 36.8 ml/min/100 g to 50.9 ml/min/100 g liver (p less than 0.02). The liver volume showed a tendency to increase but was significantly higher in only three of the seven volunteers investigated. The mean liver volumes of 1483 g before and 1585 g after antipyrine administration were not significantly different. In contrast, total liver blood flow increased significantly from 590 ml/min before to 809 ml/min after enzyme induction (p less than 0.02).
通过安替比林和苯巴比妥诱导大鼠和猴子的肝脏微粒体酶系统后，发现其肝脏血流量增加，这构成了本项针对7名志愿者研究的基础。测量了安替比林的全身清除率、γ-谷氨酰转移酶（gamma GT）以及d-葡萄糖醛酸和6-β-羟基皮质醇的尿排泄量。在基础条件下禁食过夜后，使用氙-133吸入技术估计肝脏血流量。此外，通过对肝脏进行99m锝-硫胶体扫描的7项独立研究来确定肝脏体积。之后，每位志愿者每天服用1000毫克安替比林，持续14天，然后重复所有测量。服用安替比林后，安替比林的半衰期从12.5小时显著降至7.7小时，安替比林清除率从34.1毫升/分钟增至50.8毫升/分钟。此外，葡萄糖醛酸、γ-谷氨酰转移酶和6-β-羟基皮质醇显著增加。肝脏血流量从36.8毫升/分钟/100克肝脏增至50.9毫升/分钟/100克肝脏（p＜0.02）。肝脏体积有增加的趋势，但在所研究的7名志愿者中只有3人的肝脏体积显著增大。服用安替比林前肝脏平均体积为1483克，服用后为1585克，差异不显著。相比之下，肝脏总血流量从酶诱导前的590毫升/分钟显著增至809毫升/分钟（p＜0.02）。
