Yousem S A, Colby T V, Carrington C B
Hum Pathol. 1985 Jul;16(7):700-6. doi: 10.1016/s0046-8177(85)80155-6.
Nineteen open lung biopsies demonstrating follicular bronchitis/bronchiolitis were reviewed with special attention to clinical manifestations. Morphologically, follicular bronchitis/bronchiolitis was represented by coalescent reactive germinal centers adjacent to airways in the absence of clinical or pathologic evidence of chronic obstructive pulmonary disease or bronchiectasis. Three clinicopathologic groups were identified: 1) patients with collagen vascular diseases, especially rheumatoid arthritis and Sjögren's syndrome; 2) patients with a familial form of the disease or with immunodeficiency syndromes; and 3) a heterogeneous group of patients with frequent peripheral blood eosinophilia, suggesting a hypersensitivity reaction. Prognosis was related to age at the time of biopsy and, to some extent, to the clinical group. Steroid therapy had inconsistent effects in all groups identified. The differential diagnosis of lymphoid lesions in the lung is also discussed.
对19例显示滤泡性支气管炎/细支气管炎的开放性肺活检进行了回顾，特别关注临床表现。形态学上，滤泡性支气管炎/细支气管炎表现为在无慢性阻塞性肺疾病或支气管扩张的临床或病理证据的情况下，气道旁融合的反应性生发中心。确定了三个临床病理组：1）胶原血管疾病患者，尤其是类风湿性关节炎和干燥综合征患者；2）患有家族性疾病形式或免疫缺陷综合征的患者；3）一组外周血嗜酸性粒细胞增多频繁的异质性患者，提示存在超敏反应。预后与活检时的年龄有关，在一定程度上也与临床组有关。类固醇治疗在所有确定的组中效果不一。还讨论了肺部淋巴样病变的鉴别诊断。
