Zhou Juan, Han Han, Bai Weimin
Department of Endocrinology, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, Jiangsu, China.
Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Front Aging Neurosci. 2025 Feb 26;17:1506973. doi: 10.3389/fnagi.2025.1506973. eCollection 2025.
The atherogenic index of plasma (AIP) has been proposed as a novel biomarker predictor for dyslipidemia and has been linked to various diseases. In this study, we explored the relationship between AIP levels and cognitive impairment in a middle-aged and older population.
This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) for 7,918 individuals aged 45 and older. The AIP was calculated as the logarithmic ratio of triglycerides to high-density lipoprotein cholesterol. To assess the relationship between the AIP and cognitive impairment, logistic regression models were employed, while restricted cubic spline analysis was conducted to explore potential non-linear associations between AIP levels and cognitive impairment.
The study participants had a mean age of 58.4 ± 8.8 years, and 49.1% were female. From 2011 to 2018, 2,911 participants (36.8%) developed cognitive impairment. After adjusting for potential confounders, the AIP was found to be significantly associated with cognitive impairment. In particular, participants in the higher AIP quartiles (Q2: odds ratio [OR]: 1.45, 95% confidence interval [CI]: 1.24-1.69, < 0.001, Q3: OR: 1.63, 95% CI: 1.40-1.91, < 0.001, and Q4: OR: 1.68, 95% CI: 1.43-1.98, < 0.001) showed an increased risk of cognitive impairment compared to those in the lowest quartile (Q1). Additionally, a non-linear relationship was observed between AIP levels and cognitive impairment risk (P for nonlinear < 0.001).
The study finds that elevated AIP levels are linked to an increased risk of cognitive impairment in middle-aged and older adults, suggesting that managing dyslipidemia could help reduce this risk.
血浆致动脉粥样硬化指数（AIP）已被提议作为血脂异常的一种新型生物标志物预测指标，并与多种疾病相关。在本研究中，我们探讨了中老年人群中AIP水平与认知障碍之间的关系。
本研究利用了中国健康与养老追踪调查（CHARLS）中7918名45岁及以上个体的数据。AIP计算为甘油三酯与高密度脂蛋白胆固醇的对数比值。为评估AIP与认知障碍之间的关系，采用了逻辑回归模型，同时进行了受限立方样条分析，以探讨AIP水平与认知障碍之间潜在的非线性关联。
研究参与者的平均年龄为58.4±8.8岁，49.1%为女性。从2011年到2018年，2911名参与者（36.8%）出现了认知障碍。在调整潜在混杂因素后，发现AIP与认知障碍显著相关。特别是，与最低四分位数（Q1）的参与者相比，AIP较高四分位数（Q2：比值比[OR]：1.45，95%置信区间[CI]：1.24 - 1.69，P < 0.001；Q3：OR：1.63，95% CI：1.40 - 1.91，P < 0.001；Q4：OR：1.68，95% CI：1.43 - 1.98，P < 0.001）的参与者认知障碍风险增加。此外，观察到AIP水平与认知障碍风险之间存在非线性关系（非线性P < 0.001）。
该研究发现，中老年人群中AIP水平升高与认知障碍风险增加有关，这表明控制血脂异常可能有助于降低这种风险。
