4-亚烷基-5-氨基吡唑与三氟丙酮酸甲酯的插烯官能团化反应
Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates.
作者信息
Hostalet-Romero Judit, Carceller-Ferrer Laura, Blay Gonzalo, Sanz-Marco Amparo, Pedro José R, Vila Carlos
机构信息
Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr Moliner 50, 46100 Burjassot, València, Spain.
出版信息
Beilstein J Org Chem. 2025 Mar 10;21:533-540. doi: 10.3762/bjoc.21.41. eCollection 2025.
A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group and a pyrazole ring is presented. The corresponding trifluoromethyl alcohols are obtained in moderate to good yields (up to 80%) and high diastereoselectivity (up to 7:1).
本文介绍了4-亚烷基-5-氨基吡唑与三氟丙酮酸烷基酯之间一种有价值的插烯加成反应，该反应可生成带有三氟甲基和吡唑环的高度官能化叔醇。相应的三氟甲基醇以中等至良好的产率（高达80%）和高非对映选择性（高达7:1）获得。
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