Ou Lu, Shen Quan, Xiao Meili, Wang Weihong, He Tan, Wang Binglu
Department of Basic Nursing, School of Nursing, Hunan Normal University, Changsha, China.
Department of Clinical Nursing, Xiangya Nursing School of Central South University, Changsha, China.
Psychol Med. 2025 Mar 13;55:e84. doi: 10.1017/S0033291725000601.
The prevalence of co-morbid anxiety and depression varies greatly between research studies, making it difficult to understand and estimate the magnitude of this problem. This systematic review and meta-analysis aim to provide up-to-date information on the global prevalence of co-morbid anxiety and depression in pregnant and postpartum women and to further investigate the sources of heterogeneity. Systematic searches of eight electronic databases were conducted for original studies published from inception to December 10, 2024. We selected studies that directly reported prevalence data on co-morbid anxiety and depression during the perinatal periods. We extracted data from published study reports and calculated the pooled prevalence of symptoms of co-morbid anxiety and depression. There are 122 articles involving 560,736 women from 43 different countries included in this review. The global prevalence of co-morbid anxiety and depression during the perinatal period was about 9% (95%CI 8%-10%), with approximately 9% (95%CI 8%-11%) in pregnant women and 8% (95%CI 7%-10%) in postpartum women. Prevalence varied significantly by the assessment time points, study country, study design, and the assessment tool used for anxiety and depression, while prevalence was not dependent on publication year, country income level, and COVID-19 context. No publication bias was observed for this prevalence rate. These findings suggest that approximately 1 in 10 women experience co-morbid anxiety and depression during pregnancy and postpartum. Targeted action is needed to reduce this burden.
共病焦虑和抑郁的患病率在不同研究之间差异很大，这使得难以理解和估计该问题的严重程度。本系统评价和荟萃分析旨在提供有关全球孕妇和产后妇女共病焦虑和抑郁患病率的最新信息，并进一步调查异质性来源。我们对八个电子数据库进行了系统检索，以查找从数据库建立到2024年12月10日发表的原始研究。我们选择了直接报告围产期共病焦虑和抑郁患病率数据的研究。我们从已发表的研究报告中提取数据，并计算共病焦虑和抑郁症状的合并患病率。本综述纳入了122篇文章，涉及来自43个不同国家的560,736名女性。围产期共病焦虑和抑郁的全球患病率约为9%（95%置信区间8%-10%），其中孕妇约为9%（95%置信区间8%-11%），产后妇女约为8%（95%置信区间7%-10%）。患病率因评估时间点、研究国家、研究设计以及用于焦虑和抑郁的评估工具而有显著差异，而患病率并不取决于发表年份、国家收入水平和新冠疫情背景。未观察到该患病率存在发表偏倚。这些发现表明，约十分之一的女性在孕期和产后经历共病焦虑和抑郁。需要采取有针对性的行动来减轻这一负担。
