3-氮杂-1,5-二烯的光催化区域选择性烷氧羰基化/环化反应：通往含酯基吡咯啉-2-酮的途径
Photocatalytic Regioselective Alkoxycarbonylation/Cyclization of 3-Aza-1,5-dienes: Access to Ester-Containing Pyrrolin-2-ones.
作者信息
Xiong Yuping, Zong Zhipeng, Xie Wenlin, Chen Jian-Qiang, Wu Jie
机构信息
School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China.
School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies, Taizhou University, Taizhou 318000, China.
出版信息
Org Lett. 2025 Mar 28;27(12):3037-3042. doi: 10.1021/acs.orglett.5c00694. Epub 2025 Mar 13.
A direct alkoxycarbonyl radical-induced cascade reaction of 3-aza-1,5-dienes with alkyl chlorooxoacetates is reported. With this approach, an extensive range of ester-containing pyrrolin-2-ones are synthesized through photocatalyzed alkoxycarbonylation/cyclization with 3-aza-1,5-dienes under mild conditions. Moreover, dehydrogenative aromatization can proceed with the same photocatalytic system.
报道了一种由直接的烷氧羰基自由基引发的3-氮杂-1,5-二烯与氯代氧代乙酸烷基酯的串联反应。通过这种方法，在温和条件下，利用光催化烷氧羰基化/环化反应，以3-氮杂-1,5-二烯合成了一系列含酯基的吡咯啉-2-酮。此外，相同的光催化体系还能进行脱氢芳构化反应。
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