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胰岛素抵抗的心肌梗死患者的循环瘦素和抵抗素水平

Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance.

作者信息

Dera Ayed A

机构信息

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.

出版信息

J Int Med Res. 2025 Mar;53(3):3000605251325162. doi: 10.1177/03000605251325162. Epub 2025 Mar 13.

DOI:10.1177/03000605251325162
PMID:40079443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12059967/
Abstract

ObjectiveThe study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients.MethodsThis cross-sectional study conducted from January to April 2021 at the Prince Faisal Bin Khalid Cardiac Center, Abha, Saudi Arabia, examined cardiovascular and diabetic biomarkers, including HOMA-IR, in MI patients and controls to assess insulin resistance (IR), risk, and diagnostic accuracy.ResultsMI patients showed significantly elevated HOMA-IR, leptin, resistin, body mass index (BMI), and glucose-complexed hemoglobin (HbA1c) levels compared with controls in both genders ( < 0.0001). HbA1c was strongly associated with HOMA-IR, whereas age, BMI, leptin, and resistin showed weak correlations. Elevated HOMA-IR increased MI risk and demonstrated high diagnostic accuracy.ConclusionsElevated HOMA-IR was identified as an early indicator of the onset of MI, whereas serum leptin and resistin levels exhibited a positive association with IR in patients with MI. Moreover, serum leptin, resistin, and elevated HOMA-IR may independently contribute to the risk of MI.

摘要

目的

本研究调查了胰岛素抵抗稳态模型评估（HOMA-IR）与心肌梗死（MI）参数之间的联系，强调了其作为沙特南部患者潜在MI生物标志物的作用。

方法

本横断面研究于2021年1月至4月在沙特阿拉伯阿卜哈的费萨尔·本·哈立德王子心脏中心进行，检测了MI患者和对照组的心血管和糖尿病生物标志物，包括HOMA-IR，以评估胰岛素抵抗（IR）、风险和诊断准确性。

结果

与对照组相比，MI患者的HOMA-IR、瘦素、抵抗素、体重指数（BMI）和糖化血红蛋白（HbA1c）水平在男女两性中均显著升高（<0.0001）。HbA1c与HOMA-IR密切相关，而年龄、BMI、瘦素和抵抗素显示出较弱的相关性。HOMA-IR升高增加了MI风险，并显示出较高的诊断准确性。

结论

HOMA-IR升高被确定为MI发病的早期指标，而血清瘦素和抵抗素水平在MI患者中与IR呈正相关。此外，血清瘦素、抵抗素和升高的HOMA-IR可能独立导致MI风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/30578b22b8fb/10.1177_03000605251325162-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/371a3625f750/10.1177_03000605251325162-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/a849c6d54602/10.1177_03000605251325162-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/d718a54c3b37/10.1177_03000605251325162-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/30578b22b8fb/10.1177_03000605251325162-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/371a3625f750/10.1177_03000605251325162-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/a849c6d54602/10.1177_03000605251325162-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/d718a54c3b37/10.1177_03000605251325162-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5373/12059967/30578b22b8fb/10.1177_03000605251325162-fig4.jpg

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