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3D打印技术在糖尿病足溃疡治疗中的应用:血糖控制与伤口护理的综合策略

The application of 3D printing technology in the treatment of diabetic foot ulcers: an integrated strategy for glycemic control and wound care.

作者信息

Liao Ying-Ju, Chen Chao-Yi, Lin Hsien-Te, Pei Dee, Liang Yao-Jen

机构信息

Department of Research and Development, Merdury Biopharmaceutical Corporation, New Taipei City, Taiwan, ROC.

Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

出版信息

Expert Rev Endocrinol Metab. 2025 May;20(3):201-209. doi: 10.1080/17446651.2025.2467658. Epub 2025 Mar 13.

Abstract

INTRODUCTION

Diabetic foot ulcers (DFUs) are a severe complication of diabetes, often leading to amputation. Hyperglycemia induced nerve and vascular damage significantly increases DFU risk. The advent of 3D printing technology presents a revolutionary concurrently address glycemic control and wound management, potentially improving patient adherence and offering a more holistic treatment strategy.

METHODS

This article reviews current oral antidiabetic medications and explores the potential of innovative 3D printing technology to develop extended release tablets in two distinct release profiles. Additionally, it investigates the application of this technology in creating novel wound dressing solutions aimed at facilitating DFU healing. .

RESULTS

The integration of 3D printing technology enables the production of customized, extended-release oral medications that optimize glycemic control while minimizing fluctuations in blood sugar levels. Furthermore, 3D-printed wound dressings demonstrate promising potentialfor enhancing wound healing by providing personalized structural support and controlled drug delivery.

CONCLUSION

A multidisciplinary approach that integrates advanced wound care and diabetes management is crucial to address the escalating challenges posed by DFUs. Leveraging3D printing technology to develop sustained-release medications and innovative wound dressingsmay significantly improve DFU outcomes and improve the quality of life for individuals with diabetes.

摘要

引言

糖尿病足溃疡(DFUs)是糖尿病的一种严重并发症,常导致截肢。高血糖引起的神经和血管损伤显著增加了DFU的风险。3D打印技术的出现带来了一场革命,它可以同时解决血糖控制和伤口管理问题,有可能提高患者的依从性,并提供更全面的治疗策略。

方法

本文回顾了当前的口服抗糖尿病药物,并探讨了创新的3D打印技术开发两种不同释放曲线的缓释片剂的潜力。此外,还研究了该技术在创建旨在促进DFU愈合的新型伤口敷料解决方案中的应用。

结果

3D打印技术的整合能够生产定制的缓释口服药物,在优化血糖控制的同时最大限度地减少血糖水平的波动。此外,3D打印的伤口敷料通过提供个性化的结构支持和可控的药物递送,在促进伤口愈合方面显示出有前景的潜力。

结论

整合先进伤口护理和糖尿病管理的多学科方法对于应对DFUs带来的不断升级的挑战至关重要。利用3D打印技术开发缓释药物和创新伤口敷料可能会显著改善DFU的治疗效果,并提高糖尿病患者的生活质量。

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