Nakagawa T, Miyamoto T
Int Arch Allergy Appl Immunol. 1985;77(1-2):204-5. doi: 10.1159/000233787.
Sera from 40 asthmatic patients and from 77 bee keepers were evaluated by solid-phase radioimmunoassay for their allergen-specific IgG4 antibody levels. The results indicated that allergen-specific IgG4 antibodies become prominent upon repeated parenteral stimulation with antigen, i.e. immunotherapy and bee stings, and suggested the possible association of IgG4 with blocking antibodies in these allergic conditions.
采用固相放射免疫分析法对40例哮喘患者和77例养蜂人的血清进行了过敏原特异性IgG4抗体水平评估。结果表明，在反复经抗原进行胃肠外刺激（即免疫疗法和蜂蜇）后，过敏原特异性IgG4抗体显著升高，这表明在这些过敏情况下IgG4可能与封闭抗体有关。
