Rebelo Artur, Friedrichs Juliane, Grilli Maurizio, Vey Johannes, Klose Johannes, Merling Marie, Kleeff Joerg, Ronellenfitsch Ulrich
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University of Halle Wittenberg Faculty of Medicine, Halle (Saale), Germany
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University of Halle Wittenberg Faculty of Medicine, Halle (Saale), Germany.
BMJ Open. 2025 Mar 13;15(3):e093561. doi: 10.1136/bmjopen-2024-093561.
Oesophageal cancer is the seventh most frequently diagnosed cancer and the sixth leading cause of cancer-related deaths worldwide. Oesophagectomy remains the main curative treatment option. The effect of different surgical approaches (completely open, hybrid, completely minimally invasive and robot-assisted) on patients undergoing thoracoabdominal oesophagectomy (Ivor-Lewis's procedure) for oesophageal cancer is evaluated, focusing on overall survival, postoperative mortality and morbidity.
A systematic literature search will be conducted in PubMed/Medline, Cochrane Library, Embase, Cumulated Index in Nursing and Allied Health Literature, ClinicalTrials.gov and International Clinical Trials Registry Platform using predefined search terms. A random-effects (network) meta-analysis using the frequentist framework will be performed.
As this study is based on previously published data, no ethical approval is required. Findings will be disseminated through peer-reviewed publications and conference presentations to inform clinical decision-makers (eg, surgeons, gastroenterologists).
CRD42024564915.
食管癌是全球第七大最常被诊断出的癌症，也是癌症相关死亡的第六大主要原因。食管切除术仍然是主要的根治性治疗选择。本研究评估了不同手术方式（完全开放、杂交、完全微创和机器人辅助）对接受胸腹段食管癌食管切除术（艾弗·刘易斯手术）患者的影响，重点关注总生存期、术后死亡率和发病率。
将使用预定义的检索词在PubMed/Medline、Cochrane图书馆、Embase、护理及相关健康文献累积索引、ClinicalTrials.gov和国际临床试验注册平台上进行系统的文献检索。将采用频率学派框架进行随机效应（网络）荟萃分析。
由于本研究基于先前发表的数据，无需伦理批准。研究结果将通过同行评审出版物和会议报告进行传播，以为临床决策者（如外科医生、胃肠病学家）提供参考。
CRD42024564915。
