嗜血杆菌杀菌因子的作用方式。

Mode of action of the Haemophilus bactericidal factor.

作者信息

Streker R G, Venezia R A, Robertson R G

出版信息

Antimicrob Agents Chemother. 1978 Mar;13(3):527-32. doi: 10.1128/AAC.13.3.527.

DOI:10.1128/AAC.13.3.527

PMID:400827

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352275/

Abstract

Haemocin, a bacteriocin produced by Haemophilus influenzae b, caused pronounced cell elongation of the sensitive strains H. influenzae Rd and Escherichia coli CR34 thyA. In the sensitive strains, haemocin markedly inhibited the synthesis of deoxyribonucleic acid (DNA) but did not affect either ribonucleic acid or protein synthesis. The observed inhibition in synthesis of DNA was not due to degradation of preexisting DNA. The data suggest that haemocin may specifically inhibit DNA synthesis.

摘要

流感嗜血杆菌b产生的细菌素——血杀菌素，可使敏感菌株流感嗜血杆菌Rd和大肠杆菌CR34 thyA出现明显的细胞伸长。在这些敏感菌株中，血杀菌素显著抑制脱氧核糖核酸（DNA）的合成，但不影响核糖核酸或蛋白质的合成。观察到的DNA合成抑制并非由于预先存在的DNA降解所致。这些数据表明，血杀菌素可能特异性抑制DNA合成。