Gunderson L L, Russell A H, Llewellyn H J, Doppke K P, Tepper J E
Int J Radiat Oncol Biol Phys. 1985 Jul;11(7):1379-93. doi: 10.1016/0360-3016(85)90255-x.
For colorectal cancer, the adjuvant radiation dose levels required to achieve a high incidence of local control closely parallel the radiation tolerance of small bowel (4500-5000 rad), and for patients with partially resected or unresected disease, the dose levels exceed tolerance (6000-7000 rad). Therefore, both the surgeon and the radiation oncologist should use techniques that localize tumor volumes and decrease the amount of small intestine within the irradiation field. Surgical options include pelvic reconstruction (reperitonealization, omental flaps, retroversion of uterus, etc.) and clip placement. Radiation options include the use of radiographs to define small bowel location and mobility combined with treatment techniques using multiple fields, bladder distention, shrinking or boost fields, and/or patient position changes (prone, decubitus, etc.). When both specialties interact in optimum fashion, local control can be increased with minimal risks to achieve a suitable therapeutic ratio.
对于结直肠癌,实现高局部控制率所需的辅助放疗剂量水平与小肠的放射耐受性密切平行(4500 - 5000拉德),而对于部分切除或未切除疾病的患者,剂量水平超过耐受性(6000 - 7000拉德)。因此,外科医生和放射肿瘤学家都应采用能够定位肿瘤体积并减少照射野内小肠量的技术。手术选择包括盆腔重建(重新腹膜化、网膜瓣、子宫后倾等)和夹子放置。放疗选择包括使用X光片来确定小肠位置和活动度,结合使用多野、膀胱充盈、缩野或加量野以及/或患者体位改变(俯卧位、侧卧位等)的治疗技术。当两个专业以最佳方式相互协作时,可以在将风险降至最低的情况下提高局部控制率,以实现合适的治疗比。