Klinedinst Tara C, Hollman Nicholas, Hankes Michael J, Jones Raymond
Department of Rehabilitation Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Internal Medicine, OU-TU School of Community Medicine, Tulsa, OK, USA.
J Appl Gerontol. 2025 Mar 13:7334648251325623. doi: 10.1177/07334648251325623.
Social cohesion, a measure of community belonging, and inflammatory biomarkers, like interleukin-6 (IL-6) and c-reactive protein (CRP), have emerged as significant factors influencing age-related chronic conditions and functional decline among older adults. Understanding the link between social cohesion and inflammation is particularly relevant in aging populations, as with age, social networks often diminish, and the prevalence of inflammatory conditions increases. Using data from the National Health and Aging Trends Study (NHATS), we assessed the relationship between low social cohesion and IL-6 and CRP. We found that low social cohesion was associated with higher levels of CRP and IL-6 after adjusting for the influence of sociodemographic variables. These findings could inform health policies and community-level interventions designed to enhance social cohesion for aging adults.
社会凝聚力，一种衡量社区归属感的指标，以及炎症生物标志物，如白细胞介素-6（IL-6）和C反应蛋白（CRP），已成为影响老年人与年龄相关的慢性病和功能衰退的重要因素。了解社会凝聚力与炎症之间的联系在老龄化人口中尤为重要，因为随着年龄的增长，社交网络往往会减少，而炎症性疾病的患病率会增加。利用国家健康与老龄化趋势研究（NHATS）的数据，我们评估了低社会凝聚力与IL-6和CRP之间的关系。我们发现，在调整了社会人口统计学变量的影响后，低社会凝聚力与较高水平的CRP和IL-6相关。这些发现可为旨在增强老年人社会凝聚力的卫生政策和社区层面干预措施提供参考。
