Microbial phosphorylation of compactin (ML-236B) and related compounds.
作者信息
Endo A, Yamashita H, Naoki H, Iwashita T, Mizukawa Y
出版信息
J Antibiot (Tokyo). 1985 Mar;38(3):328-32. doi: 10.7164/antibiotics.38.328.
PMID:4008328
Abstract
Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR, 13C NMR and 31P NMR spectroscopy. Related structures (monacolin K, L and X) were also transformed to their corresponding phosphorylated analogues. The products were re-converted back to respective parental compounds by treatment with alkaline phosphatase of calf intestine.
摘要
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