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Microbial phosphorylation of compactin (ML-236B) and related compounds.

作者信息

Endo A, Yamashita H, Naoki H, Iwashita T, Mizukawa Y

出版信息

J Antibiot (Tokyo). 1985 Mar;38(3):328-32. doi: 10.7164/antibiotics.38.328.

DOI:10.7164/antibiotics.38.328
PMID:4008328
Abstract

Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR, 13C NMR and 31P NMR spectroscopy. Related structures (monacolin K, L and X) were also transformed to their corresponding phosphorylated analogues. The products were re-converted back to respective parental compounds by treatment with alkaline phosphatase of calf intestine.

摘要

相似文献

1
Microbial phosphorylation of compactin (ML-236B) and related compounds.
J Antibiot (Tokyo). 1985 Mar;38(3):328-32. doi: 10.7164/antibiotics.38.328.
2
Microbial hydroxylation of compactin (ML-236B) and monacolin K.
J Antibiot (Tokyo). 1985 May;38(5):605-9. doi: 10.7164/antibiotics.38.605.
3
6 alpha-Hydroxy-iso-ML-236B (6 alpha-hydroxy-iso-compactin) and ML-236A, microbial transformation products of ML-236B.
J Antibiot (Tokyo). 1983 Jul;36(7):918-20. doi: 10.7164/antibiotics.36.918.
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Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B).ML-236B（美伐他汀）和莫纳可林K（MB-530B）的微生物羟基化作用
J Antibiot (Tokyo). 1983 May;36(5):604-7. doi: 10.7164/antibiotics.36.604.
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Formation of dihydroxy derivative of ML-236B from ML-236B (compactin) by lipid peroxidation.
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3 alpha-Hydroxy-ML-236B (3 alpha-hydroxycompactin), microbial transformation product of ML-236B (compactin).
J Antibiot (Tokyo). 1983 May;36(5):608-10. doi: 10.7164/antibiotics.36.608.
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Microbial hydroxylation of ML-236B (compactin). Studies on microorganisms capable of 3 beta-hydroxylation of ML-236B.
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Microbial conversion of compactin (ML-236B) to ML-236A.
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Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase.美伐他汀（ML-236B）及相关化合物作为潜在的降胆固醇药物，可抑制HMG-CoA还原酶。
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