Lianou P E, Bassaris H P, Votta E G, Papavassiliou J T
J Antimicrob Chemother. 1985 Apr;15(4):481-7. doi: 10.1093/jac/15.4.481.
The effect of pre-incubation of Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus mirabilis with sub-inhibitory concentrations (sub MICs) of clindamycin on the adherence of these organisms was studied. Culturing these organisms in the presence of clindamycin (4 mg/l) resulted in significant enhancement of adherence for Ps. aeruginosa and Pr. mirabilis and decreased adherence for K. pneumoniae. Furthermore, the effect of pre-exposure to clindamycin on polymorphonuclear leukocyte (PMNLs) function against these organisms was determined. Filtrates of Pr. mirabilis pre-exposed to clindamycin promoted PMNL chemotaxis. No effect on chemotaxis was noted with the filtrates of clindamycin treated Ps. aeruginosa and K. pneumoniae. PMNL phagocytosis for all the organisms was increased after they were pre-exposed to clindamycin.
研究了将铜绿假单胞菌、肺炎克雷伯菌和奇异变形杆菌与亚抑菌浓度（亚 MIC）的克林霉素预孵育对这些微生物黏附的影响。在克林霉素（4 mg/l）存在的情况下培养这些微生物，导致铜绿假单胞菌和奇异变形杆菌的黏附显著增强，而肺炎克雷伯菌的黏附则降低。此外，还确定了预先暴露于克林霉素对多形核白细胞（PMNLs）针对这些微生物的功能的影响。预先暴露于克林霉素的奇异变形杆菌滤液促进了 PMNL 的趋化作用。经克林霉素处理的铜绿假单胞菌和肺炎克雷伯菌的滤液对趋化作用没有影响。所有微生物在预先暴露于克林霉素后，PMNL 的吞噬作用均增强。
