Faden H, Hong J J, Ogra P L
J Antimicrob Chemother. 1983 Oct;12 Suppl C:29-34. doi: 10.1093/jac/12.suppl_c.29.
Neutrophil functions were evaluated in six normal subjects who had received 300 mg of clindamycin orally four times each day for two days. The mean serum concentration was 1.0 mg/l at the time of neutrophil collection. Clindamycin increased phagocytosis of a clindamycin-resistant staphylococcus from 0.8 to 1.0 organism per polymorphonuclear leukocyte (P less than 0.05). The proportion of killed intracellular bacteria increased from 23.8% to 29.8%. Zymosan-induced chemiluminescence was reduced from 130 X 10(3) to 86 X 10(3) counts per 0.2 min (P less than 0.05). Chemotaxis was unaffected. These preliminary results demonstrate measurable effects of clindamycin on neutrophil functions in the host; however, further studies are needed in order to confirm the observed changes.
对6名正常受试者的中性粒细胞功能进行了评估，这些受试者每天口服300毫克克林霉素，共服用4次，持续两天。在采集中性粒细胞时，平均血清浓度为1.0毫克/升。克林霉素使对克林霉素耐药的葡萄球菌的吞噬作用从每多形核白细胞0.8个菌体增加到1.0个菌体（P<0.05）。细胞内被杀死细菌的比例从23.8%增加到29.8%。酵母聚糖诱导的化学发光从每分钟0.2次的130×10³计数降至86×10³计数（P<0.05）。趋化性未受影响。这些初步结果表明克林霉素对宿主中性粒细胞功能有可测量的影响；然而，需要进一步研究以证实观察到的变化。
