Berardi Audrey, Brown Jennifer A, Jackson Brooke S, Huang Ling-Yu, Trotti Rebekah L, Parker David A, Hill Scot K, Ivleva Elena, Pearlson Godfrey D, Tamminga Carol A, Keshavan Matcheri S, Keedy Sarah K, Gershon Elliot S, Sweeney John A, Clementz Brett A, McDowell Jennifer E
Department of Psychology, University of Georgia, Athens, Georgia, USA.
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Bipolar Disord. 2025 May;27(3):205-216. doi: 10.1111/bdi.70010. Epub 2025 Mar 14.
This study aimed to evaluate associations in bipolar disorder (BD) across multimodal measures of white matter microstructure (using diffusion tensor imaging; DTI), cognitive, behavioral, and brain electrophysiological measures (using electroencephalography; EEG).
Subjects were recruited through the Psychosis and Affective Research Domains and Intermediate Phenotypes Consortium (n = 45 bipolar with psychosis, n = 40 bipolar without psychosis, n = 66 healthy subjects). DTI data were used to quantify the white matter variables, fractional anisotropy (FA) and radial diffusivity (RD). The Brief Assessment of Cognition in Schizophrenia (BACS), Stop Signal Task (SST), pro- and anti-saccades, auditory event-related potentials (ERPs), and intrinsic brain activity were used as estimates of brain function.
The combined BD group differed from healthy controls, but no differences between BD with and without psychosis were observed. BD-related white matter abnormalities were seen across multiple tracts: right cingulum-cingulate gyrus, bilateral anterior thalamic radiation, bilateral superior longitudinal fasciculus, right inferior longitudinal fasciculus, and forceps major. Results also showed modestly compromised cognitive performance and elevated intrinsic EEG activity associated with BD.
Further analysis indicated worse white matter integrity related to higher intrinsic EEG and modestly higher ERPs. These multimodal analyses are likely to aid in creating future informative diagnostic, etiological, and treatment targets for BD.
本研究旨在评估双相情感障碍（BD）在白质微观结构的多模态测量（使用扩散张量成像；DTI）、认知、行为和脑电生理测量（使用脑电图；EEG）方面的关联。
通过精神病与情感研究领域及中间表型联盟招募受试者（45例伴有精神病性症状的双相情感障碍患者、40例无精神病性症状的双相情感障碍患者、66例健康受试者）。DTI数据用于量化白质变量，即分数各向异性（FA）和径向扩散率（RD）。使用精神分裂症认知简短评估量表（BACS）、停止信号任务（SST）、同向和异向扫视、听觉事件相关电位（ERP）以及脑内在活动作为脑功能的评估指标。
双相情感障碍合并组与健康对照组不同，但未观察到伴有和不伴有精神病性症状的双相情感障碍患者之间存在差异。在多个脑区观察到与双相情感障碍相关的白质异常：右侧扣带束 - 扣带回、双侧丘脑前辐射、双侧上纵束、右侧下纵束和胼胝体压部。结果还显示双相情感障碍患者的认知表现略有受损，且与脑电活动增强有关。
进一步分析表明，较高的脑电活动和略高的ERP与较差的白质完整性有关。这些多模态分析可能有助于为双相情感障碍创建未来有用的诊断、病因和治疗靶点。
