Byer W L
J Chem Inf Comput Sci. 1985 May;25(2):84-90. doi: 10.1021/ci00046a006.
This paper describes a methodology that was designed to assist the Environmental Protection Agency in setting priorities for regulating chemicals in accordance with requirements of the Toxic Substances Control Act by indicating the extent of exposure potentially associated with a particular use of a chemical. Development and application of the methodology to actual chemical uses proceeded in four stages: (1) development of an exposure classification scheme, (2) development of a chemical use list, (3) assignment of exposure category scores to chemical uses, and (4) merging of exposure scores into ranked groups, creating the Index of Exposure. The purpose of the Index was to identify those chemical uses having the greatest potential for human and environmental exposure. Theoretically, the objectivity of the scoring methodology is such that, given the same data for a chemical use, different scorers will be able to arrive at the same exposure score for that use.
本文介绍了一种方法，该方法旨在通过表明与化学品特定用途潜在相关的接触程度，协助美国环境保护局根据《有毒物质控制法》的要求确定化学品监管的优先次序。该方法的开发和应用于实际化学品用途分为四个阶段：（1）制定接触分类方案；（2）制定化学品用途清单；（3）为化学品用途分配接触类别分数；（4）将接触分数合并为排名组，创建接触指数。该指数的目的是识别那些对人类和环境接触潜力最大的化学品用途。从理论上讲，评分方法的客观性在于，对于化学品用途的相同数据，不同的评分者将能够得出该用途相同的接触分数。
