Merkus J M, Roozen P H, Verhoeven A G, Kock H C
Eur J Obstet Gynecol Reprod Biol. 1978 Apr;8(2):99-102. doi: 10.1016/0028-2243(78)90135-1.
The effect of metabolite VIII of bromhexine on surfactant content in the amniotic fluid was investigated in a double blind study. Administration of 100 and 200 mg NA-872 daily for 5 days to pregnant women ranging in gestational age from 196 to 243 days was not followed by a significant rise in the L/S ratio.