Krieglsteiner P, Lohninger A, Münnich W, Neiss A, Blümel G
Z Geburtshilfe Perinatol. 1978 Feb;182(1):16-28.
The effect of Betamethasone and Bromhexine-Metabolite VIII, commonly used in RDS-prevention, was studied in pregnant rats and rabbits. 73 rats and 78 rabbits were treated for 4 days with doses, similar to those used in men. Cesarean section was performed in rats from the 18th-21th day of gestation (23 days), in rabbits from 27th-30th day (32 days). In the amniotic fluid, in fetal and maternal lungs the total phospholipid content, percentage of lecithins in total phospholipids and palmitic acid were determined and used as parameters for the surfactant content. There was no sign of induction with regard to synthesis. Premature deliveries and malformed fetusses were frequently observed under steroid-therapy. Clinical application should therefore be observed more critically.
对常用于预防呼吸窘迫综合征（RDS）的倍他米松和溴己新代谢物VIII在妊娠大鼠和家兔中的作用进行了研究。73只大鼠和78只家兔接受了为期4天的剂量治疗，剂量与人类使用的剂量相似。在妊娠第18至21天（23天）对大鼠进行剖宫产，在妊娠第27至30天（32天）对家兔进行剖宫产。测定羊水、胎儿和母体肺中的总磷脂含量、总磷脂中卵磷脂的百分比以及棕榈酸，并将其用作表面活性剂含量的参数。在合成方面没有诱导迹象。在类固醇治疗下经常观察到早产和畸形胎儿。因此，临床应用应更加严格地观察。
