Liu Defang, Yan Jiao, Luo Ting, Yang Ling
Department of Traditional Chinese Medicine, The General Hospital of Western Theater Command, No. 270 Tianhui Road, Chengdu, 610083, Sichuan, China.
Sci Rep. 2025 Mar 14;15(1):8905. doi: 10.1038/s41598-025-93720-z.
The poor prognosis of rheumatoid arthritis (RA) and its potential for complications highlight the importance of understanding factors that are associated with incidence and mortality rates. The inclusion criteria of this study were RA-related data from 1999 to 2018 in the National Health and Nutrition Examination Survey (NHANES) dataset. Based on certain screening criteria, a total of 610 subjects were recruited. The Low CRP group (< 3 mg/L) and the High CRP group (> 3 mg/L) were significantly different in gender, poverty-to-income ratio, body mass index, hypertension, hemoglobin (Hb), hematocrit, and mean corpuscular hemoglobin. KM survival result revealed that male RA patients in the Low Hb group had a significantly lower survival rate than those in the High Hb group (P < 0.0001), while female RA patients in the Low Hb group showed no statistically significant difference compared with the High Hb group (P = 0.13). Importantly, there was a nonlinear relationship between Hb and all-cause mortality in RA patients. In this study, we identified Hb as a protective factor against CRP in RA patients and also observed its association with the prognosis of RA. Consequently, regulating Hb levels might be considered to be associated with the progression of RA.
类风湿关节炎（RA）的预后较差及其并发症的可能性凸显了了解与发病率和死亡率相关因素的重要性。本研究的纳入标准是1999年至2018年美国国家健康与营养检查调查（NHANES）数据集中与RA相关的数据。基于某些筛选标准，共招募了610名受试者。低CRP组（<3mg/L）和高CRP组（>3mg/L）在性别、贫困收入比、体重指数、高血压、血红蛋白（Hb）、血细胞比容和平均红细胞血红蛋白方面存在显著差异。KM生存结果显示，低Hb组的男性RA患者生存率显著低于高Hb组（P<0.0001），而低Hb组的女性RA患者与高Hb组相比无统计学显著差异（P=0.13）。重要的是，RA患者的Hb与全因死亡率之间存在非线性关系。在本研究中，我们确定Hb是RA患者中对抗CRP的保护因素，并观察到其与RA预后的关联。因此，调节Hb水平可能被认为与RA的进展有关。
