The Second Affiliated Hospital & Yuying Children's Hospital/The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, China.
Front Immunol. 2024 Jun 19;15:1390453. doi: 10.3389/fimmu.2024.1390453. eCollection 2024.
Fibroblast growth factors (FGFs) are a versatile family of peptide growth factors that are involved in various biological functions, including cell growth and differentiation, embryonic development, angiogenesis, and metabolism. Abnormal FGF/FGF receptor (FGFR) signaling has been implicated in the pathogenesis of multiple diseases such as cancer, metabolic diseases, and inflammatory diseases. It is worth noting that macrophage polarization, which involves distinct functional phenotypes, plays a crucial role in tissue repair, homeostasis maintenance, and immune responses. Recent evidence suggests that FGF/FGFR signaling closely participates in the polarization of macrophages, indicating that they could be potential targets for therapeutic manipulation of diseases associated with dysfunctional macrophages. In this article, we provide an overview of the structure, function, and downstream regulatory pathways of FGFs, as well as crosstalk between FGF signaling and macrophage polarization. Additionally, we summarize the potential application of harnessing FGF signaling to modulate macrophage polarization.
成纤维细胞生长因子（Fibroblast growth factors，FGFs）是一类多功能的肽类生长因子，参与多种生物学功能，包括细胞生长和分化、胚胎发育、血管生成和代谢。异常的 FGF/FGF 受体（FGFR）信号与多种疾病的发病机制有关，如癌症、代谢疾病和炎症性疾病。值得注意的是，巨噬细胞极化涉及不同的功能表型，在组织修复、稳态维持和免疫反应中起着至关重要的作用。最近的证据表明，FGF/FGFR 信号通路密切参与巨噬细胞的极化，表明它们可能是治疗与功能失调的巨噬细胞相关疾病的潜在靶点。在本文中，我们概述了 FGFs 的结构、功能和下游调控途径，以及 FGF 信号与巨噬细胞极化之间的相互作用。此外，我们总结了利用 FGF 信号调节巨噬细胞极化的潜在应用。
