Auritt W A, McGeady S J, Mansmann H C
J Allergy Clin Immunol. 1985 Jun;75(6):731-5. doi: 10.1016/0091-6749(85)90102-2.
Ten ambulatory subjects with asthma experienced a seizure while they were receiving oral theophylline preparations and were evaluated prospectively according to a set protocol. The protocol included a lumbar puncture that permitted the simultaneous determination of plasma and cerebrospinal fluid (CSF) theophylline concentrations. A constant relationship was observed between the plasma theophylline concentration and that of the CSF. It was found that the theophylline concentrations in these two biologic fluids could be characterized by the regression equation y = 0.41 X + 0.7 where y is the CSF theophylline concentration and X is the plasma theophylline concentration. Two infants with hydrocephalus treated by ventriculoperitoneal shunt were also simultaneously evaluated for plasma and CSF theophylline concentrations. These infants demonstrated greater than expected entry of theophylline into the CSF. Some central nervous system abnormalities may be characterized by increased theophylline entry into the CSF.
10名患有哮喘的门诊患者在接受口服茶碱制剂时发生了惊厥，并按照既定方案进行了前瞻性评估。该方案包括腰椎穿刺，以便同时测定血浆和脑脊液（CSF）中的茶碱浓度。观察到血浆茶碱浓度与脑脊液中的浓度之间存在恒定关系。发现这两种生物流体中的茶碱浓度可用回归方程y = 0.41X + 0.7来表征，其中y是脑脊液中的茶碱浓度，X是血浆中的茶碱浓度。对2名接受脑室腹腔分流术治疗的脑积水婴儿也同时进行了血浆和脑脊液茶碱浓度评估。这些婴儿脑脊液中茶碱的进入量高于预期。某些中枢神经系统异常可能表现为茶碱进入脑脊液的量增加。
