Oki J, Yamamoto M, Yanagawa J, Ikeda K, Taketazu M, Miyamoto A
Department of Pediatrics, Asahikawa Medical College, Japan.
Brain Dev. 1994 Mar-Apr;16(2):162-4. doi: 10.1016/0387-7604(94)90057-4.
The case is presented of a 6-month-old girl with theophylline-induced focal seizures associated with tachycardia, tremor and irritability. The serum level of theophylline was 20.0 micrograms/ml 30 min after the onset of seizures, and declined to half this level at 19 h. The ratio of the concentration in cerebrospinal fluid (CSF; 8.9 micrograms/ml) to serum (16.4 micrograms/ml) was 0.54 at 4.5 h after the onset. Despite the cessation of seizures, the EEG showed periodic high voltage delta waves over the right hemisphere and left-sided flatness. Since theophylline diffuses easily through the blood-brain barrier in infancy, serum levels should be maintained below 15 micrograms/ml unless severe bronchial asthma occurs.
本文报告了一例6个月大的女孩，因茶碱诱发局灶性癫痫发作，并伴有心动过速、震颤和易怒。癫痫发作开始后30分钟，血清茶碱水平为20.0微克/毫升，19小时后降至该水平的一半。发作后4.5小时，脑脊液（CSF；8.9微克/毫升）与血清（16.4微克/毫升）的浓度比为0.54。尽管癫痫发作停止，但脑电图显示右半球有周期性高电压δ波，左侧平坦。由于茶碱在婴儿期容易通过血脑屏障扩散，除非发生严重支气管哮喘，血清水平应维持在15微克/毫升以下。
