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1
How we treat severe atopic dermatitis.我们如何治疗重度特应性皮炎。
Ann Allergy Asthma Immunol. 2025 Jun;134(6):660-663. doi: 10.1016/j.anai.2025.03.005. Epub 2025 Mar 13.
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Treatment of Severe Atopic Dermatitis with Dupilumab in Patients with Advanced Cancer.度普利尤单抗治疗晚期癌症患者的重度特应性皮炎
J Clin Med. 2023 Feb 2;12(3):1191. doi: 10.3390/jcm12031191.
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Early and Sustained Improvements in Symptoms and Quality of Life with Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: 52-Week Results from Two Phase III Randomized Clinical Trials (Measure Up 1 and Measure Up 2).度普利尤单抗治疗成人和青少年中重度特应性皮炎的疗效和生活质量：两项 III 期随机临床试验（Measure Up 1 和 Measure Up 2）的 52 周结果。
Am J Clin Dermatol. 2024 May;25(3):485-496. doi: 10.1007/s40257-024-00853-4. Epub 2024 Mar 25.
4
Economic Evaluation of Dupilumab for Moderate-to-Severe Atopic Dermatitis: A Cost-Utility Analysis.度普利尤单抗治疗中重度特应性皮炎的经济学评估：一项成本效用分析。
J Drugs Dermatol. 2018 Jul 1;17(7):750-756.
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Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial.奥马珠单抗治疗重度小儿特应性皮炎的效果：ADAPT随机临床试验
JAMA Pediatr. 2020 Jan 1;174(1):29-37. doi: 10.1001/jamapediatrics.2019.4476.
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Therapy of atopic eczema.特应性皮炎的治疗。
GMS Health Technol Assess. 2006 Oct 6;2:Doc19.
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Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial.度普利尤单抗联合局部皮质类固醇治疗青少年和成人中重度特应性皮炎（AD Up）的安全性和有效性：一项随机、双盲、安慰剂对照、3 期临床试验的结果。
Lancet. 2021 Jun 5;397(10290):2169-2181. doi: 10.1016/S0140-6736(21)00589-4. Epub 2021 May 21.
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Azathioprine as a therapeutic modality for the treatment of severe adult atopic dermatitis.硫唑嘌呤作为治疗重度成人特应性皮炎的一种治疗方式。
Indian J Dermatol Venereol Leprol. 2001 Jul-Aug;67(4):189-91.
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Efficacy and Safety of Upadacitinib Treatment in Adolescents With Moderate-to-Severe Atopic Dermatitis: Analysis of the Measure Up 1, Measure Up 2, and AD Up Randomized Clinical Trials.乌帕替尼治疗中重度特应性皮炎青少年患者的疗效和安全性：Measure Up 1、Measure Up 2 和 AD Up 随机临床试验分析。
JAMA Dermatol. 2023 May 1;159(5):526-535. doi: 10.1001/jamadermatol.2023.0391.
10
Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials.每日一次乌帕替尼对比安慰剂治疗中重度特应性皮炎青少年和成人患者（Measure Up1 和 Measure Up2）：两项复制性、双盲、随机对照 3 期临床试验结果。
Lancet. 2021 Jun 5;397(10290):2151-2168. doi: 10.1016/S0140-6736(21)00588-2. Epub 2021 May 21.

本文引用的文献

1
Disease burden and patient characteristics associated with systemic therapy utilization among adults with atopic dermatitis: data from CorEvitas Atopic Dermatitis Registry.特应性皮炎患者接受系统治疗的疾病负担和患者特征：来自 CorEvitas 特应性皮炎登记研究的数据。
J Dermatolog Treat. 2024 Dec;35(1):2396382. doi: 10.1080/09546634.2024.2396382. Epub 2024 Sep 25.
2
Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations.特应性皮炎（湿疹）指南：2023 年美国过敏、哮喘和免疫学学会/美国过敏、哮喘和免疫学学会联合工作组关于实践参数的推荐意见，基于 GRADE 分级和医学研究所的建议。
Ann Allergy Asthma Immunol. 2024 Mar;132(3):274-312. doi: 10.1016/j.anai.2023.11.009. Epub 2023 Dec 18.
3
Bleach baths enhance skin barrier, reduce itch but do not normalize skin dysbiosis in atopic dermatitis.洗米水疗法可增强皮肤屏障功能、减轻瘙痒，但不能使特应性皮炎的皮肤微生态失调正常化。
Arch Dermatol Res. 2023 Dec;315(10):2883-2892. doi: 10.1007/s00403-023-02723-1. Epub 2023 Sep 27.
4
Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.特应性皮炎（湿疹）的全身治疗：随机试验的系统评价和网状Meta分析
J Allergy Clin Immunol. 2023 Dec;152(6):1470-1492. doi: 10.1016/j.jaci.2023.08.029. Epub 2023 Sep 9.
5
Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.特应性皮炎（湿疹）的局部治疗：随机试验的系统评价和网状荟萃分析
J Allergy Clin Immunol. 2023 Dec;152(6):1493-1519. doi: 10.1016/j.jaci.2023.08.030. Epub 2023 Sep 9.
6
Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment.达必妥治疗特应性皮炎患者后金黄色葡萄球菌迅速减少。
J Allergy Clin Immunol. 2023 Nov;152(5):1179-1195. doi: 10.1016/j.jaci.2023.05.026. Epub 2023 Jun 13.
7
Comorbidities of atopic dermatitis-what does the evidence say?特应性皮炎的共病情况——现有证据如何说明？
J Allergy Clin Immunol. 2023 May;151(5):1155-1162. doi: 10.1016/j.jaci.2022.12.002. Epub 2023 Jan 6.
8
Therapeutic inertia in the management of patients with inadequately controlled atopic dermatitis.特应性皮炎控制不佳患者管理中的治疗惰性
J Eur Acad Dermatol Venereol. 2022 Oct;36(10):e817-e818. doi: 10.1111/jdv.18303. Epub 2022 Jun 25.
9
Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons.特应性皮炎主动局部治疗的评估：利弊。
Am J Clin Dermatol. 2021 Nov;22(6):775-783. doi: 10.1007/s40257-021-00629-0. Epub 2021 Jul 28.
10
The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis.英国特应性皮炎工作组诊断标准。I. 特应性皮炎最小鉴别指标集的推导。
Br J Dermatol. 1994 Sep;131(3):383-96. doi: 10.1111/j.1365-2133.1994.tb08530.x.

How we treat severe atopic dermatitis.

作者信息

Chinchilli Ellen, De Benedetto Anna, Beck Lisa A

机构信息

Department of Dermatology, University of Rochester Medical Center, Rochester, New York.

Department of Dermatology, University of Rochester Medical Center, Rochester, New York; Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.

出版信息

Ann Allergy Asthma Immunol. 2025 Jun;134(6):660-663. doi: 10.1016/j.anai.2025.03.005. Epub 2025 Mar 13.

DOI:10.1016/j.anai.2025.03.005
PMID:40088946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12160583/
Abstract
摘要