Department of Dermatology and Venerology, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, 8200, Aarhus, Denmark.
Department of Dermatology and Venerology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Am J Clin Dermatol. 2021 Nov;22(6):775-783. doi: 10.1007/s40257-021-00629-0. Epub 2021 Jul 28.
Atopic dermatitis is a common inflammatory skin disease that can affect both children and adults. It is a chronic disease with recurrent, highly pruritic eczematous lesions. Topical treatment with anti-inflammatory agents is the mainstay of treatment for atopic dermatitis, either in a reactive or proactive approach according to severity of the disease and always in combination with daily application of an emollient cream. Several studies have shown that proactive therapy with either topical corticosteroids or topical calcineurin inhibitors is significantly superior at reducing the number of flares and increasing the interval between flares compared with reactive therapy in patients with moderate and severe disease. The risk of side effects is considered low, and there seem to be no extra economic costs related to this treatment approach. Proactive therapy is an advisable treatment option for patients with moderate and severe atopic dermatitis to gain prolonged disease control; however, long-term safety data and data on when to stop do not yet exist.
特应性皮炎是一种常见的炎症性皮肤病，可影响儿童和成人。它是一种慢性疾病，反复发作，高度瘙痒的湿疹病变。局部应用抗炎药是特应性皮炎治疗的主要方法，无论是根据疾病的严重程度采取反应性治疗还是预防性治疗，并且始终与每日使用保湿霜相结合。多项研究表明，与反应性治疗相比，中重度疾病患者采用局部皮质类固醇或局部钙调神经磷酸酶抑制剂进行预防性治疗可显著减少发作次数并延长发作间隔。副作用风险被认为较低，而且这种治疗方法似乎不会带来额外的经济成本。对于中重度特应性皮炎患者，预防性治疗是一种合理的治疗选择，可获得长期疾病控制；然而，目前尚无长期安全性数据和何时停止治疗的数据。
