Reiter L W, MacPhail R C
Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Neurobehav Toxicol. 1979;1 Suppl 1:53-66.
Activity measurements are expected to have widespread use in toxicity testing. The multifaceted nature of motor activity will directly influence the selection of a measurement technique since the relative contribution of various motor acts to any particular measurement will depend upon the detection method. Because of the apparatus-dependent nature of motor activity measurements, it is recommended that consideration be given to how accurately the various devices measure locomotor activity. In the present paper, two types of body movement will be considered as locomotor activity: ambulation (horizontally directed movement) and rearing (vertically directed movement). Discussion focuses on the various methods currently used to record motor activity, the various components of motor activity which are likely to be recorded, and the advantages and disadvantages of these techniques for the measurement of locomotor activity. Finally, consideration is given to studies which have compared treatment effects on motor activity derived from two or more measurement techniques.
活性测量有望在毒性测试中得到广泛应用。运动活性的多面性将直接影响测量技术的选择，因为各种运动行为对任何特定测量的相对贡献将取决于检测方法。由于运动活性测量依赖于仪器，建议考虑各种设备测量运动活性的准确性。在本文中，两种身体运动将被视为运动活性：行走（水平方向的运动）和竖毛（垂直方向的运动）。讨论的重点是目前用于记录运动活性的各种方法、可能被记录的运动活性的各种组成部分，以及这些技术在测量运动活性方面的优缺点。最后，考虑了比较两种或更多测量技术对运动活性的治疗效果的研究。
