Semanate Fernando, Tarupi Wilmer, Fernandez Trokhimtchouk Tatiana, Palacios Christian, Jaramillo Oscar
Surgical Oncology, Hospital de Especialidades Carlos Andrade Marin, Quito, ECU.
National Tumor Registry Coordination, Hospital Oncológico Solón Espinosa Ayala (SOLCA), Quito, ECU.
Cureus. 2025 Feb 12;17(2):e78897. doi: 10.7759/cureus.78897. eCollection 2025 Feb.
This study aimed to investigate the utility of measuring parathyroid hormone (PTH) levels as a predictor of hypocalcemia in a population of patients undergoing total thyroidectomy for thyroid cancer between 2016 and 2019. We conducted an observational, analytical, descriptive, cross-sectional investigation, assessing PTH levels as a predictor of hypocalcemia following thyroidectomy. Among patients with hypoparathyroidism, 25.5% experienced hypocalcemia, while 74.5% had normal serum calcium levels. The likelihood of hypocalcemia was five times higher in patients with hypoparathyroidism (OR: 5.43; 95% CI: 1.89-15.6), a statistically significant finding (p < 0.05). Additionally, PTH values at 24 hours post-surgery averaged 28.9 pg/mL (SD: 30.8 pg/mL), ranging from 0.01 to 235 pg/mL. Serum calcium levels averaged 8.31 mg/dL (SD: 0.74), with values ranging from 6.5 to 10.6 mg/dL. The study demonstrates a statistically significant association between PTH levels and post-surgical serum calcium levels, albeit with moderate predictive power. These findings support the utility of PTH measurement in predicting hypocalcemia following thyroidectomy, underscoring its potential clinical relevance in patient management.
本研究旨在调查在2016年至2019年间接受甲状腺癌全甲状腺切除术的患者群体中，测量甲状旁腺激素（PTH）水平作为低钙血症预测指标的效用。我们进行了一项观察性、分析性、描述性横断面调查，评估PTH水平作为甲状腺切除术后低钙血症的预测指标。在甲状旁腺功能减退的患者中，25.5%出现了低钙血症，而74.5%的患者血清钙水平正常。甲状旁腺功能减退患者发生低钙血症的可能性高出五倍（比值比：5.43；95%置信区间：1.89 - 15.6），这是一个具有统计学意义的发现（p < 0.05）。此外，术后24小时的PTH值平均为28.9 pg/mL（标准差：30.8 pg/mL），范围为0.01至235 pg/mL。血清钙水平平均为8.31 mg/dL（标准差：0.74），值范围为6.5至10.6 mg/dL。该研究表明PTH水平与术后血清钙水平之间存在统计学上的显著关联，尽管预测能力中等。这些发现支持了PTH测量在预测甲状腺切除术后低钙血症方面的效用，强调了其在患者管理中的潜在临床相关性。
