Hang Zhenyu, Wang Li, Zhang Liangping
Department of Urology, Liyang People's Hospital Liyang 213300, Jiangsu, China.
Intensive Care Unit, Liyang People's Hospital Liyang 213300, Jiangsu, China.
Am J Transl Res. 2025 Feb 15;17(2):992-1004. doi: 10.62347/VFFF7133. eCollection 2025.
To evaluate the predictive value of procalcitonin (PCT) in assessing the therapeutic response of patients with uroseptic shock.
This retrospective case-control study included 220 patients treated for uroseptic shock at Liyang People's Hospital between January 2018 and December 2023. Patients were classified into high-risk (HR) (n = 116) and low-risk (LR) (n = 104) groups based on their Sepsis-related Organ Failure Assessment (SOFA) scores after 14 days of treatment. Demographic, clinical, and laboratory data were collected, and PCT levels were measured using chemiluminescence. Correlation analysis and receiver operating characteristic (ROC) curve analysis were used to assess the predictive value of PCT.
The HR group had significantly higher PCT levels (25.33 ± 5.32 ng/mL) compared to the LR group (18.47 ± 2.88 ng/mL, P < 0.001). Elevated PCT levels were strongly correlated with poor therapeutic response (rho = -0.635, P < 0.001). Other markers, including hypertension (rho = -0.207, P = 0.002), CRP (rho = -0.224, P < 0.001), IL-6 (rho = -0.200, P = 0.003), TNF-α (rho = -0.151, P = 0.025), NEUT% (rho = -0.208, P = 0.002), GGT (rho = -0.160, P = 0.017), and BUN (rho = -0.198, P = 0.003), also showed significant negative correlations with treatment outcome. Conversely, PLT (rho = 0.156, P = 0.021) and the CD4+/CD8+ ratio (rho = 0.242, P < 0.001) were positively correlated with better treatment outcome. ROC analysis revealed an area under the curve (AUC) of 0.867 for PCT, indicating its strong predictive value.
PCT level is a robust predictor of therapeutic response in uroseptic shock patients and may be integrated into clinical protocols for sepsis management.
评估降钙素原（PCT）在评估尿源性脓毒症休克患者治疗反应中的预测价值。
这项回顾性病例对照研究纳入了2018年1月至2023年12月期间在溧阳市人民医院接受尿源性脓毒症休克治疗的220例患者。根据治疗14天后的脓毒症相关器官功能衰竭评估（SOFA）评分，将患者分为高危（HR）组（n = 116）和低危（LR）组（n = 104）。收集人口统计学、临床和实验室数据，并使用化学发光法测量PCT水平。采用相关性分析和受试者工作特征（ROC）曲线分析来评估PCT的预测价值。
与LR组（18.47±2.88 ng/mL）相比，HR组的PCT水平显著更高（25.33±5.32 ng/mL，P < 0.001）。PCT水平升高与治疗反应不佳密切相关（rho = -0.635，P < 0.001）。其他指标，包括高血压（rho = -0.207，P = 0.002）、CRP（rho = -0.224，P < 0.001）、IL-6（rho = -0.200，P = 0.003）、TNF-α（rho = -0.151，P = 0.025）、中性粒细胞百分比（rho = -0.208，P = 0.002）、γ-谷氨酰转移酶（rho = -0.160，P = 0.017）和血尿素氮（rho = -0.
