Saleem Sahibzadi Saira, Bibi Rukhsana, Gillani Syed Muhammad Usama Mohyuddin, Alqahtani Naji, Syed Wajid, Ibrar Muhammad, Iqbal Muhammad Omer, Rehman Tanzila, Arshad Hafiz M, Khan Imran Ahmad
Department of Chemistry, The Woman University Multan 60000, Punjab, Pakistan.
Ali Ul Murtaza, Department of Rehabilitation Sciences, Muhammad Institute of Medical and Allied Sciences Multan 60000, Punjab, Pakistan.
Am J Transl Res. 2025 Feb 15;17(2):1018-1028. doi: 10.62347/ZRFI2658. eCollection 2025.
The study aimed to evaluate the synergistic effects of Majoon-e-Suranjaan with and without isometric exercises in patients with rheumatoid arthritis (RA).
A prospective, pragmatic, community based, parallel group, single blinded randomized controlled trial conducted at Muhammad Physical Therapy and Rehabilitation Clinic and Rehabilitation Centre, Multan, from May to October 2023. The trial was approved and registered in the Iranian Registry of Clinical Trials (IRCT20230202057310N5). Ninety-five patients were randomly assigned to two groups. Group A received Majoon-e-Suranjaan (5 g orally, twice daily). Group B received the same dosage of Majoon-e-Suranjaan along with The isometric exercises. The exercise protocol for group B consisted of three weekly sessions, each lasting 40 minutes. Patients were evaluated at baseline and at the 24 week based on serological markers, including rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), disease activity score (DAS), and C-reactive protein (CRP), as well as X-ray findings such as nodules and bone degeneration in affected joints. Pain, morning stiffness, and functional activities were assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the Numerical Pain Rating Scale (NPRS).
Of the 95 patients randomized, 90 completed the 24-week treatment. Among them, 60 (66.6%) were female, and 30 (33.3%) were male. Group B showed significantly greater improvements compared to Group A in in WOMAC activities of daily living (P=0.001), WOMAC stiffness (P=0.004), WOMAC pain and DAS (P=0.000), NPRS (P=0.001). Additionally, Group B demonstrated significant improvements in RF (P=0.001), ESR (P=0.002), and CRP (P=0.003) compared to group A.
This study demonstrated the synergistic effect of Majoon-e-Suranjaan and isometric exercises in RA patients, highlighting the potential for more effective RA treatment strategies.
本研究旨在评估舒兰詹丸（Majoon-e-Suranjaan）在有或没有等长运动的情况下对类风湿关节炎（RA）患者的协同作用。
这是一项前瞻性、实用性、基于社区的平行组单盲随机对照试验，于2023年5月至10月在木尔坦的穆罕默德物理治疗与康复诊所及康复中心进行。该试验已在伊朗临床试验注册中心（IRCT20230202057310N5）获得批准并注册。95名患者被随机分为两组。A组口服舒兰詹丸（5克，每日两次）。B组接受相同剂量的舒兰詹丸并进行等长运动。B组的运动方案包括每周三次，每次持续40分钟。在基线和第24周时，根据血清学指标对患者进行评估，包括类风湿因子（RF）、红细胞沉降率（ESR）、疾病活动评分（DAS）和C反应蛋白（CRP），以及X线检查结果，如受累关节的结节和骨质退变。使用西安大略和麦克马斯特大学关节炎指数（WOMAC）和数字疼痛评分量表（NPRS）评估疼痛、晨僵和功能活动。
在随机分组的95名患者中，90名完成了24周的治疗。其中，60名（66.6%）为女性，30名（33.3%）为男性。与A组相比，B组在WOMAC日常生活活动（P=0.001）、WOMAC僵硬（P=0.004）、WOMAC疼痛和DAS（P=0.000）、NPRS（P=0.001）方面有显著更大的改善。此外，与A组相比，B组在RF（P=0.001）、ESR（P=0.002）和CRP（P=0.003）方面有显著改善。
本研究证明了舒兰詹丸和等长运动对RA患者的协同作用，突出了更有效RA治疗策略的潜力。
