Roy Mainak, Reddy Mulagondla Harshavardhan, Das Deepanjan, Chandrakar Denish, Elavarasu A Muhil
Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Department of Orthopaedics, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
J Orthop Case Rep. 2025 Mar;15(3):265-274. doi: 10.13107/jocr.2025.v15.i03.5408.
Rotator cuff tendinopathy often causes significant shoulder pain and limits function. Traditional treatments, such as physical therapy and corticosteroid injections, provide inconsistent relief. Platelet-rich plasma (PRP) has emerged as a promising regenerative therapy for pain relief and tendon healing. This systematic review and meta-analysis evaluated PRP's effectiveness compared to placebo or other treatments.
A thorough search of PubMed, Embase, and Cochrane Library focused on randomized controlled trials (RCTs) using PRP as a primary intervention for rotator cuff tendinopathy. Eligible studies included pain reduction, functional improvement, and retear rates as outcomes. Data were extracted and analyzed using standardized methods.
Thirty RCTs with around 2,500 participants were included in the study. PRP significantly reduced pain and improved function in the short term compared to placebo and corticosteroids. However, long-term benefits (beyond 12 months) were limited, with retear rates and function similar to control groups.
PRP provides significant short-term pain relief and functional improvement in rotator cuff tendinopathy but does not demonstrate superior long-term benefits over placebo or corticosteroids.
肩袖肌腱病常导致严重的肩部疼痛并限制功能。传统治疗方法，如物理治疗和皮质类固醇注射，缓解效果不一。富血小板血浆（PRP）已成为一种有前景的用于缓解疼痛和促进肌腱愈合的再生疗法。本系统评价和荟萃分析评估了PRP与安慰剂或其他治疗方法相比的有效性。
全面检索了PubMed、Embase和Cochrane图书馆，重点关注使用PRP作为肩袖肌腱病主要干预措施的随机对照试验（RCT）。符合条件的研究将疼痛减轻、功能改善和再撕裂率作为观察指标。采用标准化方法提取和分析数据。
该研究纳入了30项随机对照试验，约2500名参与者。与安慰剂和皮质类固醇相比，PRP在短期内显著减轻了疼痛并改善了功能。然而，长期益处（超过12个月）有限，再撕裂率和功能与对照组相似。
PRP在肩袖肌腱病中提供了显著的短期疼痛缓解和功能改善，但与安慰剂或皮质类固醇相比，并未显示出优越的长期益处。
