Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Vascular Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Medicine (Baltimore). 2021 Oct 15;100(41):e27526. doi: 10.1097/MD.0000000000027526.
The effect of platelet-rich plasma (PRP) on patients with acute Achilles tendon rupture is still controversial. The purpose of this systematic review is to assess the efficacy of PRP injections treating acute Achilles tendon rupture.
A comprehensive electronic literature search was performed in the PubMed, Embase, Cochrane Library, and Web of Science databases to identify relevant studies that were published prior to April 29, 2021. Randomized controlled trials evaluating the efficacy of PRP injections in treating patients with acute Achilles tendon rupture were included. Statistical analyses were conducted using RevMan software.
Five randomized controlled trials were included in this systematic review. The results of the meta-analysis showed that PRP has positive effects on ankle dorsiflexion angle, dorsal extension strength of the ankle, and calf circumference compared with that in controls. However, the current evidence failed to show that PRP effectively improves ankle plantar flexion angle, plantar flexion strength of the ankle, and pain.
PRP injections for the treatment of acute Achilles tendon rupture significantly improved ankle dorsiflexion angle, dorsal extension strength of the ankle, and calf circumference compared with that in controls. Additional studies with larger sample sizes, more rigorous designs and standardized protocols are needed to draw more reliable and accurate conclusions.
富血小板血浆（PRP）对急性跟腱断裂患者的影响仍存在争议。本系统评价的目的是评估 PRP 注射治疗急性跟腱断裂的疗效。
在 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库中进行全面的电子文献检索，以确定截至 2021 年 4 月 29 日之前发表的相关研究。纳入评估 PRP 注射治疗急性跟腱断裂患者疗效的随机对照试验。使用 RevMan 软件进行统计分析。
本系统评价纳入了 5 项随机对照试验。荟萃分析结果表明，与对照组相比，PRP 对踝关节背屈角度、踝关节背伸力量和小腿围度有积极影响。然而，目前的证据表明 PRP 并不能有效改善踝关节跖屈角度、踝关节跖屈力量和疼痛。
与对照组相比，PRP 注射治疗急性跟腱断裂可显著改善踝关节背屈角度、踝关节背伸力量和小腿围度。需要更多具有更大样本量、更严格设计和标准化方案的研究来得出更可靠和准确的结论。
